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Created page with "fRNA Functional RNA. A non-coding RNA (ncRNA) is a functional RNA molecule that is not translated into a protein. Less..."

fRNA
Functional RNA.
A non-coding RNA (ncRNA) is a functional RNA molecule that is not translated into a protein. Less-frequently used synonyms are non-protein-coding RNA (npcRNA), non-messenger RNA (nmRNA), small non-messenger RNA (snmRNA) and functional RNA (fRNA). The term small RNA (sRNA) is often used for small bacterial ncRNAs. The DNA sequence from which a non-coding RNA is transcribed as the end product is often called an RNA gene or non-coding RNA gene.
Non-coding RNA genes include highly abundant and functionally important RNAs such as transfer RNA (tRNA) and ribosomal RNA (rRNA), as well as RNAs such as snoRNAs, microRNAs, siRNAs and piRNAs and the long ncRNAs that include examples such as Xist and HOTAIR (see here for a more complete list of ncRNAs). The number of ncRNAs encoded within the human genome is unknown, however recent transcriptomic and bioinformatic studies suggest the existence of thousands of ncRNAs.[1][2][3], but see [4] Since many of the newly identified ncRNAs have not been validated for their function, it is possible that many are non-functional.[5]

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<h2>Contents</h2>
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<ul style="display: none">
<li class="toclevel-1 tocsection-1">1 History and discovery</li>
<li class="toclevel-1 tocsection-2">2 Biological roles of ncRNA 
<ul>
<li class="toclevel-2 tocsection-3">2.1 ncRNAs in translation</li>
<li class="toclevel-2 tocsection-4">2.2 ncRNAs in RNA splicing</li>
<li class="toclevel-2 tocsection-5">2.3 ncRNAs in gene regulation 
<ul>
<li class="toclevel-3 tocsection-6">2.3.1 trans-acting ncRNAs</li>
<li class="toclevel-3 tocsection-7">2.3.2 cis-acting ncRNAs</li>
</ul>
</li>
<li class="toclevel-2 tocsection-8">2.4 ncRNAs and genome defense</li>
<li class="toclevel-2 tocsection-9">2.5 ncRNAs and chromosome structure</li>
<li class="toclevel-2 tocsection-10">2.6 Bifunctional RNA</li>
</ul>
</li>
<li class="toclevel-1 tocsection-11">3 ncRNAs and disease 
<ul>
<li class="toclevel-2 tocsection-12">3.1 Cancer</li>
<li class="toclevel-2 tocsection-13">3.2 Prader–Willi syndrome</li>
<li class="toclevel-2 tocsection-14">3.3 Autism</li>
<li class="toclevel-2 tocsection-15">3.4 Cartilage-hair hypoplasia</li>
<li class="toclevel-2 tocsection-16">3.5 Alzheimer's disease</li>
<li class="toclevel-2 tocsection-17">3.6 miR-96 and hearing loss</li>
</ul>
</li>
<li class="toclevel-1 tocsection-18">4 Distinction between functional RNA (fRNA) and ncRNA</li>
<li class="toclevel-1 tocsection-19">5 See also</li>
<li class="toclevel-1 tocsection-20">6 References</li>
<li class="toclevel-1 tocsection-21">7 External links</li>
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<h2>History and discovery</h2>
<div class="rellink boilerplate further">Further information: History of molecular biology</div>
Nucleic acids were first discovered in 1868 by Friedrich Miescher[6] and by 1939 RNA had been implicated in protein synthesis.[7] Two decades later, Francis Crick predicted a functional RNA component which mediated translation; he reasoned that RNA is better suited to base-pair with the mRNA transcript than a pure polypeptide.[8]
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<div style="width: 252px" class="thumbinner"><img class="thumbimage" alt="" src="http://upload.wikimedia.org/wikipedia/commons/thumb/b/ba/TRNA-Phe_yeast_1ehz.png/250px-TRNA-Phe_yeast_1ehz.png" width="250" height="247" /> 
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<div class="magnify"><img alt="" src="http://bits.wikimedia.org/skins-1.17/common/images/magnify-clip.png" width="15" height="11" /></div>
The cloverleaf structure of Yeast tRNAPhe (inset) and the 3D structure determined by X-ray analysis.</div>
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The first non-coding RNA to be characterised was an alanine tRNA found in baker's yeast, its structure was published in 1965.[9] To produce a purified alanine tRNA sample, Robert W. Holley et al. used 140kg of commercial baker's yeast to give just 1g of purified tRNAAla for analysis.[10] The 80 nucleotide tRNA was sequenced by first being digested with Pancreatic ribonuclease (producing fragments ending in Cytosine or Uridine) and then with takadiastase ribonuclease Tl (producing fragments which finished with Guanosine). Chromatography and identification of the 5' and 3' ends then helped arrange the fragments to establish the RNA sequence.[10] Of the three structures originally proposed for this tRNA,[9] the 'cloverleaf' structure was independently proposed in several following publications.[11][12][13][14] The cloverleaf secondary structure was finalised following X-ray crystallography anaylsis performed by two independent research groups in 1974.[15][16]
Ribosomal RNA was next to be discovered, followed by URNA in the early 1980s. Since then, the discovery of new non-coding RNAs has continued with snoRNAs, Xist, CRISPR and many more.[17] Recent notable additions include riboswitches and miRNA, the discovery of the RNAi mechanism associated with the latter earned Craig C. Mello and Andrew Fire the 2006 Nobel Prize in Physiology or Medicine.[18]
<h2>Biological roles of ncRNA</h2>
Noncoding RNAs belong to several groups and are involved in many cellular processes. These range from ncRNAs of central importance that are conserved across all or most cellular life through to more transient ncRNAs specific to one or a few closely related species. The more conserved ncRNAs are thought to be molecular fossils or relics from LUCA and the RNA world.[19][20][21]
<h3>ncRNAs in translation</h3>
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<div style="width: 402px" class="thumbinner"><img class="thumbimage" alt="" src="http://upload.wikimedia.org/wikipedia/commons/thumb/e/e6/NcRNAs-central-dogma.svg/400px-NcRNAs-central-dogma.svg.png" width="400" height="203" /> 
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<div class="magnify"><img alt="" src="http://bits.wikimedia.org/skins-1.17/common/images/magnify-clip.png" width="15" height="11" /></div>
An illustration of the central dogma of molecular biology annotated with the processes ncRNAs are involved in. RNPs are shown in red, ncRNAs are shown in blue.</div>
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<div style="width: 222px" class="thumbinner"><img class="thumbimage" alt="" src="http://upload.wikimedia.org/wikipedia/commons/thumb/c/c6/10_large_subunit.gif/220px-10_large_subunit.gif" width="220" height="220" /> 
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<div class="magnify"><img alt="" src="http://bits.wikimedia.org/skins-1.17/common/images/magnify-clip.png" width="15" height="11" /></div>
Atomic structure of the 50S Subunit from Haloarcula marismortui. Proteins are shown in blue and the two RNA strands in orange and yellow.[22] The small patch of green in the center of the subunit is the active site.</div>
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Many of the conserved, essential and abundant ncRNAs are involved in translation. Ribonucleoprotein (RNP) particles called ribosomes are the 'factories' where translation takes place in the cell. The ribosome consists of more than 60% ribosomal RNA, these are made up of 3 ncRNAs in prokaryotes and 4 ncRNAs in eukaryotes. Ribosomal RNAs catalyse the translation of nucleotide sequences to protein. Another set of ncRNAs, Transfer RNAs, form an 'adaptor molecule' between mRNA and protein. The H/ACA box and C/D box snoRNAs are ncRNAs found in archaea and eukaryotes, RNase MRP is restricted to eukaryotes, both groups of ncRNA are involved in the maturation of rRNA. The snoRNAs guide covalent modifications of rRNA, tRNA and snRNAs, RNase MRP cleaves the internal transcribed spacer 1 between 18S and 5.8S rRNAs. The ubiquitous ncRNA, RNase P, is an evolutionary relative of RNase MRP.[23] RNase P matures tRNA sequences by generating mature 5'-ends of tRNAs through cleaving the 5'-leader elements of precursor-tRNAs. Another ubiquitous RNP called SRP recognizes and transports specific nascent proteins to the endoplasmic reticulum in eukaryotes and the plasma membrane in prokaryotes. In bacteria Transfer-messenger RNA (tmRNA) is an RNP involved in rescuing stalled ribosomes, tagging incomplete polypeptides and promoting the degradation of aberrant mRNA.
<h3>ncRNAs in RNA splicing</h3>
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<div style="width: 222px" class="thumbinner"><img class="thumbimage" alt="" src="http://upload.wikimedia.org/wikipedia/commons/thumb/1/18/Yeast_tri-snRNP.jpg/220px-Yeast_tri-snRNP.jpg" width="220" height="160" /> 
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<div class="magnify"><img alt="" src="http://bits.wikimedia.org/skins-1.17/common/images/magnify-clip.png" width="15" height="11" /></div>
Electron microscopy images of the yeast spliceosome. Note the bulk of the complex is in fact ncRNA.</div>
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In eukaryotes the spliceosome performs the splicing reactions essential for removing intron sequences, this process is required for the formation of mature mRNA. The spliceosome is another RNP often also known as the snRNP or tri-snRNP. There are two different forms of the spliceosome, the major and minor forms. The ncRNA components of the major spliceosome are U1, U2, U4 and U5. The ncRNA components of the minor spliceosome are U11, U12, U5, U4atac and U6atac.
Another group of introns can catalyse their own removal from host transcripts, these are called self-splicing RNAs. There are two main groups of self-splicing RNAs, these are the group I catalytic intron and group II catalytic intron. These ncRNAs catalyze their own excision from mRNA, tRNA and rRNA precursors in a wide range of organisms.
In mammals it has been found that snoRNAs can also regulate the alternative splicing of mRNA, for example snoRNA HBII-52 regulates the splicing of serotonin receptor 2C.[24]
In nematodes the SmY ncRNA appears to be involved in mRNA trans-splicing.
<h3>ncRNAs in gene regulation</h3>
The expression of many thousands of genes are regulated by ncRNAs. This regulation can occur in trans or in cis.
<h4>trans-acting ncRNAs</h4>
In higher eukaryotes microRNAs regulate gene expression. A single miRNA can reduce the expression levels of hundreds of genes. The mechanism by which mature miRNA molecules act is through partial complementary to one or more messenger RNA (mRNA) molecules, generally in 3' UTRs. The main function of miRNAs is to down-regulate gene expression.
The ncRNA RNase P has also been shown to influence gene expression. In the human nucleus RNase P is required for the normal and efficient transcription of various ncRNAs transcribed by RNA polymerase III. These include tRNA, 5S rRNA, SRP RNA and U6 snRNA genes. RNase P exerts its role in transcription through association with Pol III and chromatin of active tRNA and 5S rRNA genes. [25]
It has been shown that 7SK RNA, a metazoan ncRNA, acts as a negative regulator of the RNA polymerase II elongation factor P-TEFb, and that this activity is influenced by stress response pathways.
The bacterial ncRNA, 6S RNA, specifically associates with RNA polymerase holoenzyme containing the sigma70 specificity factor. This interaction represses expression from a sigma70-dependent promoter during stationary phase.
Another bacterial ncRNA, OxyS RNA represses translation by binding to Shine-Dalgarno sequences thereby occluding ribosome binding. OxyS RNA is induced in response to oxidative stress in Escherichia coli.
The B2 RNA is a small noncoding RNA polymerase III transcript that represses mRNA transcription in response to heat shock in mouse cells. B2 RNA inhibits transcription by binding to core Pol II. Through this interaction, B2 RNA assembles into preinitiation complexes at the promoter and blocks RNA synthesis. [26]
A recent study has shown that just the act of transcription of ncRNA sequence can have an influence on gene expression. RNA polymerase II transcription of ncRNAs is required for chromatin remodelling in the Schizosaccharomyces pombe. Chromatin is progressively converted to an open configuration, as several species of ncRNAs are transcribed. [27]
<h4>cis-acting ncRNAs</h4>
<div class="rellink relarticle mainarticle">Main articles: Five prime untranslated region and Three prime untranslated region</div>
A number of ncRNAs are embedded in the 5' UTRs of protein coding genes and influence their expression in various ways. For example, a riboswitch can directly bind a small target molecule, the binding of the target affects the gene's activity.
RNA leader sequences are found upstream of the first gene of in amino acid biosynthetic operons. These RNA elements form one of two possible structures in regions encoding very short peptide sequences that are rich in the end product amino acid of the operon. A terminator structure forms when there is an excess of the regulatory amino acid and ribosome movement over the leader transcript is not impeded. When there is a deficiency of the charged tRNA of the regulatory amino acid the ribosome translating the leader peptide stalls and the antiterminator structure forms. This allows RNA polymerase to transcribe the operon. Known RNA leaders are Histidine operon leader, Leucine operon leader, Threonine operon leader and the Tryptophan operon leader.
Iron response elements (IRE) are bound by iron response proteins (IRP). The IRE is found in UTRs (Untranslated Regions) of various mRNAs whose products are involved in iron metabolism. When iron concentration is low, IRPs bind the ferritin mRNA IRE leading to translation repression.
Internal ribosome entry sites (IRES) are a RNA structure that allow for translation initiation in the middle of a mRNA sequence as part of the process of protein synthesis.
<h3>ncRNAs and genome defense</h3>
Piwi-interacting RNAs (piRNAs) expressed in mammalian testes and somatic cells, they form RNA-protein complexes with Piwi proteins. These piRNA complexes (piRCs) have been linked to transcriptional gene silencing of retrotransposons and other genetic elements in germ line cells, particularly those in spermatogenesis.
Clustered Regularly Interspaced Short Palindromic Repeats (CRISPR) are repeats found in the DNA of many bacteria and archaea. The repeats are separated by spacers of similar length. It has been demonstrated that these spacers can be derived from phage and subsequently help protect the cell from infection.
<h3>ncRNAs and chromosome structure</h3>
Telomerase is an RNP enzyme that adds specific DNA sequence repeats ("TTAGGG" in vertebrates) to telomeric regions, which are found at the ends of eukaryotic chromosomes. The telomeres contain condensed DNA material, giving stability to the chromosomes. The enzyme is a reverse transcriptase that carries Telomerase RNA, which is used as a template when it elongates telomeres, which are shortened after each replication cycle.
Xist (X-inactive-specific transcript) is an long ncRNA gene on the X chromosome of the placental mammals that acts as major effector of the X chromosome inactivation process forming Barr bodies. An antisense RNA, Tsix, is a negative regulator of Xist. X chromosomes lacking Tsix expression (and thus having high levels of Xist transcription) are inactivated more frequently than normal chromosomes. In drosophilids, which also use an XY sex-determination system, the roX (RNA on the X) RNAs are involved in dosage compensation. [28] Both Xist and roX operate by epigenetic regulation of transcription through the recruitment of histone-modifying enzymes.
<h3>Bifunctional RNA</h3>
Bifunctional RNAs are RNAs that have two distinct functions, these are also known as dual function RNAs.[29][30] The majority of the known bifunctional RNAs are both mRNAs that encode a protein and ncRNAs. However there are also a growing number of ncRNAs that fall into two different ncRNA categories e.g. H/ACA box snoRNA and miRNA.[31][32]
Two well known examples of bifunctional RNAs are SgrS RNA and RNAIII. However, a handful of other bifunctional RNAs are known to exist, e.g. SRA (Steroid Receptor Activator) ,[33] VegT RNA ,[34][35] Oskar RNA [36] and ENOD40.[37]
<h2>ncRNAs and disease</h2>
See also: Long noncoding RNAs in disease
As with proteins, mutations or imbalances in the ncRNA repertoire within the body can cause a variety of diseases.
<h3>Cancer</h3>
Many ncRNAs show abnormal expression patterns in cancerous tissues. These include miRNAs,[38] long mRNA-like ncRNAs ,[39][40] GAS5, [41] SNORD50, [42] telomerase RNA and Y RNAs. [43] The miRNAs are involved in the large scale regulation of many protein coding genes,[44][45] the Y RNAs are important for the initiation of DNA replication,[46] telomerase RNA that serves as a primer for telomerase, an RNP that extends telomeric regions at chromosome ends (see telomeres and disease for more information). The direct function of the long mRNA-like ncRNAs is less clear.
Germ-line mutations in miR-16-1 and miR-15 primary precursors have been shown to be much more frequent in patients with chronic lymphocytic leukemia compared to control populations.[47][48]
It has been suggested that a rare SNP (rs11614913) that overlaps hsa-mir-196a2 has been found to be associated with non-small cell lung carcinoma.[49] Likewise, a screen of 17 miRNAs that have been predicted to regulate a number of breast cancer associated genes found variations in the microRNAs miR-17 and miR-30c-1, these patients were noncarriers of BRCA1 or BRCA2 mutations, lending the possibility that familial breast cancer may be caused by variation in these miRNAs.[50]
<h3>Prader–Willi syndrome</h3>
The deletion of the 48 copies of the C/D box snoRNA SNORD116 has been shown to be the primary cause of Prader–Willi syndrome.[51][52][53] Prader–Willi is a developmental disorder associated with over-eating and learning difficulties. SNORD116 has potential target sites within a number of protein-coding genes, and could have a role in regulating alternative splicing.[54]
<h3>Autism</h3>
The chromosomal locus containing the small nucleolar RNA SNORD115 gene cluster has been duplicated in approximately 5% of individuals with autistic traits.[55] [56] A mouse model engineered to have a duplication of the SNORD115 cluster displays autistic-like behaviour. [57]
<h3>Cartilage-hair hypoplasia</h3>
Mutations within RNase MRP have been shown to cause cartilage-hair hypoplasia, a disease associated with an array of symptoms such as short stature, sparse hair, skeletal abnormalities and a suppressed immune system that is frequent among Amish and Finnish.[58][59][60] The best characterised variant is an A-to-G transition at nucleotide 70 that is in a loop region two bases 5' of a conserved pseudoknot. However, many other mutations within RNase MRP also cause CHH.
<h3>Alzheimer's disease</h3>
The antisense RNA, BACE1-AS is transcribed from the opposite strand to BACE1 and is upregulated in patients with Alzheimer's disease.[61] BACE1-AS regulates the expression of BACE1 by increasing BACE1 mRNA stability and generating additional BACE1 through a post-transcriptional feed-forward mechanism. By the same mechanism it also raises concentrations of beta amyloid, the main constituent of senile plaques. BACE1-AS concentrations are elevated in subjects with Alzheimer's disease and in amyloid precursor protein transgenic mice.
<h3>miR-96 and hearing loss</h3>
Variation within the seed region of mature miR-96 has been associated with autosomal dominant, progressive hearing loss in humans and mice. The homozygous mutant mice were profoundly deaf, showing no cochlear responses. Heterozygous mice and humans progressively lose the ability to hear. [62] [63] [64]
<h2>Distinction between functional RNA (fRNA) and ncRNA</h2>
Several publications[65][66][67] have started using the term functional RNA (fRNA), as opposed to ncRNA, to describe regions functional at the RNA level that may or may not be stand-alone RNA transcripts. Therefore, every ncRNA is a fRNA, but there exist fRNA (such as riboswitches, SECIS elements, and other cis-regulatory regions) that are not ncRNA. Yet the term fRNA could also include mRNA as this is RNA coding for protein and hence is functional. Additionally artificially evolved RNAs also fall under the fRNA umbrella term. Some publications[17] state that the terms ncRNA and fRNA are nearly synonymous.
<h2>See also</h2>
<ul>
<li>List of RNAs</li>
<li>Nucleic acid structure</li>
<li>Rfam</li>
<li>Riboswitch</li>
<li>Ribozyme</li>
<li>RNAs present in environmental samples</li>
</ul>
<h2>References</h2>
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<ol class="references">
<li id="cite_note-pmid15790807-0"><a href="#cite_ref-pmid15790807_0-0">^</a> Cheng J, Kapranov P, Drenkow J, Dike S, Brubaker S, Patel S, Long J, Stern D, Tammana H, Helt G, Sementchenko V, Piccolboni A, Bekiranov S, Bailey DK, Ganesh M, Ghosh S, Bell I, Gerhard DS, Gingeras TR (2005). "Transcriptional maps of 10 human chromosomes at 5-nucleotide resolution.". Science 308 (5725): 1149–54. <a title="Digital object identifier" href="/wiki/Digital_object_identifier">doi</a>:<a class="external text" href="http://dx.doi.org/10.1126%2Fscience.1108625" rel="nofollow">10.1126/science.1108625</a>. <a class="mw-redirect" title="PubMed Identifier" href="/wiki/PubMed_Identifier">PMID</a> <a class="external text" href="http://www.ncbi.nlm.nih.gov/pubmed/15790807" rel="nofollow">15790807</a>.<span class="Z3988" title="ctx_ver=Z39.88-2004&rft_val_fmt=info%3Aofi%2Ffmt%3Akev%3Amtx%3Ajournal&rft.genre=article&rft.atitle=Transcriptional+maps+of+10+human+chromosomes+at+5-nucleotide+resolution.&rft.jtitle=Science&rft.aulast=Cheng+J%2C+Kapranov+P%2C+Drenkow+J%2C+Dike+S%2C+Brubaker+S%2C+Patel+S%2C+Long+J%2C+Stern+D%2C+Tammana+H%2C+Helt+G%2C+Sementchenko+V%2C+Piccolboni+A%2C+Bekiranov+S%2C+Bailey+DK%2C+Ganesh+M%2C+Ghosh+S%2C+Bell+I%2C+Gerhard+DS%2C+Gingeras+TR&rft.au=Cheng+J%2C+Kapranov+P%2C+Drenkow+J%2C+Dike+S%2C+Brubaker+S%2C+Patel+S%2C+Long+J%2C+Stern+D%2C+Tammana+H%2C+Helt+G%2C+Sementchenko+V%2C+Piccolboni+A%2C+Bekiranov+S%2C+Bailey+DK%2C+Ganesh+M%2C+Ghosh+S%2C+Bell+I%2C+Gerhard+DS%2C+Gingeras+TR&rft.date=2005&rft.volume=308&rft.issue=5725&rft.pages=1149%E2%80%9354&rft_id=info:doi/10.1126%2Fscience.1108625&rft_id=info:pmid/15790807&rfr_id=info:sid/en.wikipedia.org:Non-coding_RNA"> </li>
<li id="cite_note-pmid17571346-1"><a href="#cite_ref-pmid17571346_1-0">^</a> ENCODE Project Consortium; Birney, E; Stamatoyannopoulos, JA; Dutta, A; Guigó, R; Gingeras, TR; Margulies, EH; Weng, Z et al. (2007). <a class="external text" href="http://www.pubmedcentral.nih.gov/articlerender.fcgi?tool=pmcentrez&artid=2212820" rel="nofollow">"Identification and analysis of functional elements in 1% of the human genome by the ENCODE pilot project."</a>. Nature 447 (7146): 799–816. <a title="Digital object identifier" href="/wiki/Digital_object_identifier">doi</a>:<a class="external text" href="http://dx.doi.org/10.1038%2Fnature05874" rel="nofollow">10.1038/nature05874</a>. <a title="PubMed Central" href="/wiki/PubMed_Central">PMC</a> <a class="external text" href="http://www.pubmedcentral.gov/articlerender.fcgi?tool=pmcentrez&artid=2212820" rel="nofollow">2212820</a>. <a class="mw-redirect" title="PubMed Identifier" href="/wiki/PubMed_Identifier">PMID</a> <a class="external text" href="http://www.ncbi.nlm.nih.gov/pubmed/17571346" rel="nofollow">17571346</a>. <a class="external free" href="http://www.pubmedcentral.nih.gov/articlerender.fcgi?tool=pmcentrez&artid=2212820" rel="nofollow">http://www.pubmedcentral.nih.gov/articlerender.fcgi?tool=pmcentrez&artid=2212820</a>.<span class="Z3988" title="ctx_ver=Z39.88-2004&rft_val_fmt=info%3Aofi%2Ffmt%3Akev%3Amtx%3Ajournal&rft.genre=article&rft.atitle=Identification+and+analysis+of+functional+elements+in+1%25+of+the+human+genome+by+the+ENCODE+pilot+project.&rft.jtitle=Nature&rft.aulast=ENCODE+Project+Consortium&rft.au=ENCODE+Project+Consortium&rft.au=Birney%2C%26%2332%3BE&rft.au=Stamatoyannopoulos%2C%26%2332%3BJA&rft.au=Dutta%2C%26%2332%3BA&rft.au=Guig%C3%B3%2C%26%2332%3BR&rft.au=Gingeras%2C%26%2332%3BTR&rft.au=Margulies%2C%26%2332%3BEH&rft.au=Weng%2C%26%2332%3BZ&rft.au=Snyder%2C%26%2332%3BM&rft.date=2007&rft.volume=447&rft.issue=7146&rft.pages=799%E2%80%93816&rft_id=info:doi/10.1038%2Fnature05874&rft_id=info:pmc/2212820&rft_id=info:pmid/17571346&rft_id=http%3A%2F%2Fwww.pubmedcentral.nih.gov%2Farticlerender.fcgi%3Ftool%3Dpmcentrez%26artid%3D2212820&rfr_id=info:sid/en.wikipedia.org:Non-coding_RNA"> </li>
<li id="cite_note-pmid17568003-2"><a href="#cite_ref-pmid17568003_2-0">^</a> Washietl S, Pedersen JS, Korbel JO, Stocsits C, Gruber AR, Hackermüller J, Hertel J, Lindemeyer M, Reiche K, Tanzer A, Ucla C, Wyss C, Antonarakis SE, Denoeud F, Lagarde J, Drenkow J, Kapranov P, Gingeras TR, Guigó R, Snyder M, Gerstein MB, Reymond A, Hofacker IL, Stadler PF (2007). <a class="external text" href="http://www.pubmedcentral.nih.gov/articlerender.fcgi?tool=pmcentrez&artid=1891344" rel="nofollow">"Structured RNAs in the ENCODE selected regions of the human genome."</a>. Genome Res 17 (6): 852–64. <a title="Digital object identifier" href="/wiki/Digital_object_identifier">doi</a>:<a class="external text" href="http://dx.doi.org/10.1101%2Fgr.5650707" rel="nofollow">10.1101/gr.5650707</a>. <a title="PubMed Central" href="/wiki/PubMed_Central">PMC</a> <a class="external text" href="http://www.pubmedcentral.gov/articlerender.fcgi?tool=pmcentrez&artid=1891344" rel="nofollow">1891344</a>. <a class="mw-redirect" title="PubMed Identifier" href="/wiki/PubMed_Identifier">PMID</a> <a class="external text" href="http://www.ncbi.nlm.nih.gov/pubmed/17568003" rel="nofollow">17568003</a>. <a class="external free" href="http://www.pubmedcentral.nih.gov/articlerender.fcgi?tool=pmcentrez&artid=1891344" rel="nofollow">http://www.pubmedcentral.nih.gov/articlerender.fcgi?tool=pmcentrez&artid=1891344</a>.<span class="Z3988" title="ctx_ver=Z39.88-2004&rft_val_fmt=info%3Aofi%2Ffmt%3Akev%3Amtx%3Ajournal&rft.genre=article&rft.atitle=Structured+RNAs+in+the+ENCODE+selected+regions+of+the+human+genome.&rft.jtitle=Genome+Res&rft.aulast=Washietl+S%2C+Pedersen+JS%2C+Korbel+JO%2C+Stocsits+C%2C+Gruber+AR%2C+Hackerm%C3%BCller+J%2C+Hertel+J%2C+Lindemeyer+M%2C+Reiche+K%2C+Tanzer+A%2C+Ucla+C%2C+Wyss+C%2C+Antonarakis+SE%2C+Denoeud+F%2C+Lagarde+J%2C+Drenkow+J%2C+Kapranov+P%2C+Gingeras+TR%2C+Guig%C3%B3+R%2C+Snyder+M%2C+Gerstein+MB%2C+Reymond+A%2C+Hofacker+IL%2C+Stadler+PF&rft.au=Washietl+S%2C+Pedersen+JS%2C+Korbel+JO%2C+Stocsits+C%2C+Gruber+AR%2C+Hackerm%C3%BCller+J%2C+Hertel+J%2C+Lindemeyer+M%2C+Reiche+K%2C+Tanzer+A%2C+Ucla+C%2C+Wyss+C%2C+Antonarakis+SE%2C+Denoeud+F%2C+Lagarde+J%2C+Drenkow+J%2C+Kapranov+P%2C+Gingeras+TR%2C+Guig%C3%B3+R%2C+Snyder+M%2C+Gerstein+MB%2C+Reymond+A%2C+Hofacker+IL%2C+Stadler+PF&rft.date=2007&rft.volume=17&rft.issue=6&rft.pages=852%E2%80%9364&rft_id=info:doi/10.1101%2Fgr.5650707&rft_id=info:pmc/1891344&rft_id=info:pmid/17568003&rft_id=http%3A%2F%2Fwww.pubmedcentral.nih.gov%2Farticlerender.fcgi%3Ftool%3Dpmcentrez%26artid%3D1891344&rfr_id=info:sid/en.wikipedia.org:Non-coding_RNA"> </li>
<li id="cite_note-3"><a href="#cite_ref-3">^</a> van Bakel H, Nislow C, Blencowe BJ, Hughes TR (2010). <a class="external text" href="http://www.plosbiology.org/article/info%3Adoi%2F10.1371%2Fjournal.pbio.1000371" rel="nofollow">"Most “dark matter” transcripts are associated with known genes"</a>. PLoS Biol 8 (5): e1000371. <a title="Digital object identifier" href="/wiki/Digital_object_identifier">doi</a>:<a class="external text" href="http://dx.doi.org/10.1371%2Fjournal.pbio.1000371" rel="nofollow">10.1371/journal.pbio.1000371</a>. <a title="PubMed Central" href="/wiki/PubMed_Central">PMC</a> <a class="external text" href="http://www.pubmedcentral.gov/articlerender.fcgi?tool=pmcentrez&artid=2872640" rel="nofollow">2872640</a>. <a class="mw-redirect" title="PubMed Identifier" href="/wiki/PubMed_Identifier">PMID</a> <a class="external text" href="http://www.ncbi.nlm.nih.gov/pubmed/20502517" rel="nofollow">20502517</a>. <a class="external free" href="http://www.plosbiology.org/article/info%3Adoi%2F10.1371%2Fjournal.pbio.1000371" rel="nofollow">http://www.plosbiology.org/article/info%3Adoi%2F10.1371%2Fjournal.pbio.1000371</a>.<span class="Z3988" title="ctx_ver=Z39.88-2004&rft_val_fmt=info%3Aofi%2Ffmt%3Akev%3Amtx%3Ajournal&rft.genre=article&rft.atitle=Most+%E2%80%9Cdark+matter%E2%80%9D+transcripts+are+associated+with+known+genes&rft.jtitle=PLoS+Biol&rft.aulast=van+Bakel+H%2C+Nislow+C%2C+Blencowe+BJ%2C+Hughes+TR&rft.au=van+Bakel+H%2C+Nislow+C%2C+Blencowe+BJ%2C+Hughes+TR&rft.date=2010&rft.volume=8&rft.issue=5&rft.pages=e1000371&rft_id=info:doi/10.1371%2Fjournal.pbio.1000371&rft_id=info:pmc/2872640&rft_id=info:pmid/20502517&rft_id=http%3A%2F%2Fwww.plosbiology.org%2Farticle%2Finfo%253Adoi%252F10.1371%252Fjournal.pbio.1000371&rfr_id=info:sid/en.wikipedia.org:Non-coding_RNA"> </li>
<li id="cite_note-pmid15851066-4"><a href="#cite_ref-pmid15851066_4-0">^</a> Hüttenhofer A, Schattner P, Polacek N (2005). "Non-coding RNAs: hope or hype?". Trends Genet 21 (5): 289–97. <a title="Digital object identifier" href="/wiki/Digital_object_identifier">doi</a>:<a class="external text" href="http://dx.doi.org/10.1016%2Fj.tig.2005.03.007" rel="nofollow">10.1016/j.tig.2005.03.007</a>. <a class="mw-redirect" title="PubMed Identifier" href="/wiki/PubMed_Identifier">PMID</a> <a class="external text" href="http://www.ncbi.nlm.nih.gov/pubmed/15851066" rel="nofollow">15851066</a>.<span class="Z3988" title="ctx_ver=Z39.88-2004&rft_val_fmt=info%3Aofi%2Ffmt%3Akev%3Amtx%3Ajournal&rft.genre=article&rft.atitle=Non-coding+RNAs%3A+hope+or+hype%3F&rft.jtitle=Trends+Genet&rft.aulast=H%C3%BCttenhofer+A%2C+Schattner+P%2C+Polacek+N&rft.au=H%C3%BCttenhofer+A%2C+Schattner+P%2C+Polacek+N&rft.date=2005&rft.volume=21&rft.issue=5&rft.pages=289%E2%80%9397&rft_id=info:doi/10.1016%2Fj.tig.2005.03.007&rft_id=info:pmid/15851066&rfr_id=info:sid/en.wikipedia.org:Non-coding_RNA"> </li>
<li id="cite_note-5"><a href="#cite_ref-5">^</a> Dahm R (February 2005). <a class="external text" href="http://linkinghub.elsevier.com/retrieve/pii/S0012-1606(04)00823-1" rel="nofollow">"Friedrich Miescher and the discovery of DNA"</a>. Dev. Biol. 278 (2): 274–88. <a title="Digital object identifier" href="/wiki/Digital_object_identifier">doi</a>:<a class="external text" href="http://dx.doi.org/10.1016%2Fj.ydbio.2004.11.028" rel="nofollow">10.1016/j.ydbio.2004.11.028</a>. <a class="mw-redirect" title="PubMed Identifier" href="/wiki/PubMed_Identifier">PMID</a> <a class="external text" href="http://www.ncbi.nlm.nih.gov/pubmed/15680349" rel="nofollow">15680349</a>. <a class="external free" href="http://linkinghub.elsevier.com/retrieve/pii/S0012-1606(04)00823-1" rel="nofollow">http://linkinghub.elsevier.com/retrieve/pii/S0012-1606(04)00823-1</a>. Retrieved 2010-09-03.<span class="Z3988" title="ctx_ver=Z39.88-2004&rft_val_fmt=info%3Aofi%2Ffmt%3Akev%3Amtx%3Ajournal&rft.genre=article&rft.atitle=Friedrich+Miescher+and+the+discovery+of+DNA&rft.jtitle=Dev.+Biol.&rft.aulast=Dahm+R&rft.au=Dahm+R&rft.date=February+2005&rft.volume=278&rft.issue=2&rft.pages=274%E2%80%9388&rft_id=info:doi/10.1016%2Fj.ydbio.2004.11.028&rft_id=info:pmid/15680349&rft_id=http%3A%2F%2Flinkinghub.elsevier.com%2Fretrieve%2Fpii%2FS0012-1606%2804%2900823-1&rfr_id=info:sid/en.wikipedia.org:Non-coding_RNA"> </li>
<li id="cite_note-6"><a href="#cite_ref-6">^</a> Caspersson T, Schultz J (1939). "Pentose nucleotides in the cytoplasm of growing tissues". Nature 143 (3623): 602–3. <a title="Digital object identifier" href="/wiki/Digital_object_identifier">doi</a>:<a class="external text" href="http://dx.doi.org/10.1038%2F143602c0" rel="nofollow">10.1038/143602c0</a>.<span class="Z3988" title="ctx_ver=Z39.88-2004&rft_val_fmt=info%3Aofi%2Ffmt%3Akev%3Amtx%3Ajournal&rft.genre=article&rft.atitle=Pentose+nucleotides+in+the+cytoplasm+of+growing+tissues&rft.jtitle=Nature&rft.aulast=Caspersson+T%2C+Schultz+J&rft.au=Caspersson+T%2C+Schultz+J&rft.date=1939&rft.volume=143&rft.issue=3623&rft.pages=602%E2%80%933&rft_id=info:doi/10.1038%2F143602c0&rfr_id=info:sid/en.wikipedia.org:Non-coding_RNA"> </li>
<li id="cite_note-7"><a href="#cite_ref-7">^</a> CRICK FH (1958). "On protein synthesis". Symp. Soc. Exp. Biol. 12: 138–63. <a class="mw-redirect" title="PubMed Identifier" href="/wiki/PubMed_Identifier">PMID</a> <a class="external text" href="http://www.ncbi.nlm.nih.gov/pubmed/13580867" rel="nofollow">13580867</a>.<span class="Z3988" title="ctx_ver=Z39.88-2004&rft_val_fmt=info%3Aofi%2Ffmt%3Akev%3Amtx%3Ajournal&rft.genre=article&rft.atitle=On+protein+synthesis&rft.jtitle=Symp.+Soc.+Exp.+Biol.&rft.aulast=CRICK+FH&rft.au=CRICK+FH&rft.date=1958&rft.volume=12&rft.pages=138%E2%80%9363&rft_id=info:pmid/13580867&rfr_id=info:sid/en.wikipedia.org:Non-coding_RNA"> </li>
<li id="cite_note-Hol65-8">^ <a href="#cite_ref-Hol65_8-0">a</a> <a href="#cite_ref-Hol65_8-1">b</a> HOLLEY RW, APGAR J, EVERETT GA, et al. (March 1965). <a class="external text" href="http://www.sciencemag.org/cgi/pmidlookup?view=long&pmid=14263761" rel="nofollow">"STRUCTURE OF A RIBONUCLEIC ACID"</a>. Science 147 (3664): 1462–5. <a title="Digital object identifier" href="/wiki/Digital_object_identifier">doi</a>:<a class="external text" href="http://dx.doi.org/10.1126%2Fscience.147.3664.1462" rel="nofollow">10.1126/science.147.3664.1462</a>. <a class="mw-redirect" title="PubMed Identifier" href="/wiki/PubMed_Identifier">PMID</a> <a class="external text" href="http://www.ncbi.nlm.nih.gov/pubmed/14263761" rel="nofollow">14263761</a>. <a class="external free" href="http://www.sciencemag.org/cgi/pmidlookup?view=long&pmid=14263761" rel="nofollow">http://www.sciencemag.org/cgi/pmidlookup?view=long&pmid=14263761</a>. Retrieved 2010-09-03.<span class="Z3988" title="ctx_ver=Z39.88-2004&rft_val_fmt=info%3Aofi%2Ffmt%3Akev%3Amtx%3Ajournal&rft.genre=article&rft.atitle=STRUCTURE+OF+A+RIBONUCLEIC+ACID&rft.jtitle=Science&rft.aulast=HOLLEY+RW%2C+APGAR+J%2C+EVERETT+GA%2C+%27%27et+al.%27%27&rft.au=HOLLEY+RW%2C+APGAR+J%2C+EVERETT+GA%2C+%27%27et+al.%27%27&rft.date=March+1965&rft.volume=147&rft.issue=3664&rft.pages=1462%E2%80%935&rft_id=info:doi/10.1126%2Fscience.147.3664.1462&rft_id=info:pmid/14263761&rft_id=http%3A%2F%2Fwww.sciencemag.org%2Fcgi%2Fpmidlookup%3Fview%3Dlong%26pmid%3D14263761&rfr_id=info:sid/en.wikipedia.org:Non-coding_RNA"> </li>
<li id="cite_note-Nobel68-9">^ <a href="#cite_ref-Nobel68_9-0">a</a> <a href="#cite_ref-Nobel68_9-1">b</a> <a class="external text" href="http://nobelprize.org/nobel_prizes/medicine/laureates/1968/index.html" rel="nofollow">"The Nobel Prize in Physiology or Medicine 1968"</a>. Nobel Foundation. <a class="external free" href="http://nobelprize.org/nobel_prizes/medicine/laureates/1968/index.html" rel="nofollow">http://nobelprize.org/nobel_prizes/medicine/laureates/1968/index.html</a>. Retrieved 2007-07-28.<span class="Z3988" title="ctx_ver=Z39.88-2004&rft_val_fmt=info%3Aofi%2Ffmt%3Akev%3Amtx%3Abook&rft.genre=bookitem&rft.btitle=The+Nobel+Prize+in+Physiology+or+Medicine+1968&rft.atitle=&rft.pub=Nobel+Foundation&rft_id=http%3A%2F%2Fnobelprize.org%2Fnobel_prizes%2Fmedicine%2Flaureates%2F1968%2Findex.html&rfr_id=info:sid/en.wikipedia.org:Non-coding_RNA"> </li>
<li id="cite_note-pmid5938777-10"><a href="#cite_ref-pmid5938777_10-0">^</a> Madison JT, Everett GA, Kung H (1966). "Nucleotide sequence of a yeast tyrosine transfer RNA.". Science 153 (735): 531–4. <a title="Digital object identifier" href="/wiki/Digital_object_identifier">doi</a>:<a class="external text" href="http://dx.doi.org/10.1126%2Fscience.153.3735.531" rel="nofollow">10.1126/science.153.3735.531</a>. <a class="mw-redirect" title="PubMed Identifier" href="/wiki/PubMed_Identifier">PMID</a> <a class="external text" href="http://www.ncbi.nlm.nih.gov/pubmed/5938777" rel="nofollow">5938777</a>.<span class="Z3988" title="ctx_ver=Z39.88-2004&rft_val_fmt=info%3Aofi%2Ffmt%3Akev%3Amtx%3Ajournal&rft.genre=article&rft.atitle=Nucleotide+sequence+of+a+yeast+tyrosine+transfer+RNA.&rft.jtitle=Science&rft.aulast=Madison+JT%2C+Everett+GA%2C+Kung+H&rft.au=Madison+JT%2C+Everett+GA%2C+Kung+H&rft.date=1966&rft.volume=153&rft.issue=735&rft.pages=531%E2%80%934&rft_id=info:doi/10.1126%2Fscience.153.3735.531&rft_id=info:pmid/5938777&rfr_id=info:sid/en.wikipedia.org:Non-coding_RNA"> </li>
<li id="cite_note-11"><a href="#cite_ref-11">^</a> Zachau HG, Dütting D, Feldmann H, Melchers F, Karau W (1966). "Serine specific transfer ribonucleic acids. XIV. Comparison of nucleotide sequences and secondary structure models". Cold Spring Harb. Symp. Quant. Biol. 31: 417–24. <a class="mw-redirect" title="PubMed Identifier" href="/wiki/PubMed_Identifier">PMID</a> <a class="external text" href="http://www.ncbi.nlm.nih.gov/pubmed/5237198" rel="nofollow">5237198</a>.<span class="Z3988" title="ctx_ver=Z39.88-2004&rft_val_fmt=info%3Aofi%2Ffmt%3Akev%3Amtx%3Ajournal&rft.genre=article&rft.atitle=Serine+specific+transfer+ribonucleic+acids.+XIV.+Comparison+of+nucleotide+sequences+and+secondary+structure+models&rft.jtitle=Cold+Spring+Harb.+Symp.+Quant.+Biol.&rft.aulast=Zachau+HG%2C+D%C3%BCtting+D%2C+Feldmann+H%2C+Melchers+F%2C+Karau+W&rft.au=Zachau+HG%2C+D%C3%BCtting+D%2C+Feldmann+H%2C+Melchers+F%2C+Karau+W&rft.date=1966&rft.volume=31&rft.pages=417%E2%80%9324&rft_id=info:pmid/5237198&rfr_id=info:sid/en.wikipedia.org:Non-coding_RNA"> </li>
<li id="cite_note-12"><a href="#cite_ref-12">^</a> Dudock BS, Katz G, Taylor EK, Holley RW (March 1969). <a class="external text" href="http://www.pubmedcentral.nih.gov/articlerender.fcgi?tool=pmcentrez&artid=223689" rel="nofollow">"Primary structure of wheat germ phenylalanine transfer RNA"</a>. Proc. Natl. Acad. Sci. U.S.A. 62 (3): 941–5. <a title="Digital object identifier" href="/wiki/Digital_object_identifier">doi</a>:<a class="external text" href="http://dx.doi.org/10.1073%2Fpnas.62.3.941" rel="nofollow">10.1073/pnas.62.3.941</a>. <a title="PubMed Central" href="/wiki/PubMed_Central">PMC</a> <a class="external text" href="http://www.pubmedcentral.gov/articlerender.fcgi?tool=pmcentrez&artid=223689" rel="nofollow">223689</a>. <a class="mw-redirect" title="PubMed Identifier" href="/wiki/PubMed_Identifier">PMID</a> <a class="external text" href="http://www.ncbi.nlm.nih.gov/pubmed/5257014" rel="nofollow">5257014</a>. <a class="external free" href="http://www.pubmedcentral.nih.gov/articlerender.fcgi?tool=pmcentrez&artid=223689" rel="nofollow">http://www.pubmedcentral.nih.gov/articlerender.fcgi?tool=pmcentrez&artid=223689</a>. Retrieved 2010-09-03.<span class="Z3988" title="ctx_ver=Z39.88-2004&rft_val_fmt=info%3Aofi%2Ffmt%3Akev%3Amtx%3Ajournal&rft.genre=article&rft.atitle=Primary+structure+of+wheat+germ+phenylalanine+transfer+RNA&rft.jtitle=Proc.+Natl.+Acad.+Sci.+U.S.A.&rft.aulast=Dudock+BS%2C+Katz+G%2C+Taylor+EK%2C+Holley+RW&rft.au=Dudock+BS%2C+Katz+G%2C+Taylor+EK%2C+Holley+RW&rft.date=March+1969&rft.volume=62&rft.issue=3&rft.pages=941%E2%80%935&rft_id=info:doi/10.1073%2Fpnas.62.3.941&rft_id=info:pmc/223689&rft_id=info:pmid/5257014&rft_id=http%3A%2F%2Fwww.pubmedcentral.nih.gov%2Farticlerender.fcgi%3Ftool%3Dpmcentrez%26artid%3D223689&rfr_id=info:sid/en.wikipedia.org:Non-coding_RNA"> </li>
<li id="cite_note-13"><a href="#cite_ref-13">^</a> Cramer F, Doepner H, Haar F VD, Schlimme E, Seidel H (December 1968). <a class="external text" href="http://www.pubmedcentral.nih.gov/articlerender.fcgi?tool=pmcentrez&artid=225267" rel="nofollow">"On the conformation of transfer RNA"</a>. Proc. Natl. Acad. Sci. U.S.A. 61 (4): 1384–91. <a title="Digital object identifier" href="/wiki/Digital_object_identifier">doi</a>:<a class="external text" href="http://dx.doi.org/10.1073%2Fpnas.61.4.1384" rel="nofollow">10.1073/pnas.61.4.1384</a>. <a title="PubMed Central" href="/wiki/PubMed_Central">PMC</a> <a class="external text" href="http://www.pubmedcentral.gov/articlerender.fcgi?tool=pmcentrez&artid=225267" rel="nofollow">225267</a>. <a class="mw-redirect" title="PubMed Identifier" href="/wiki/PubMed_Identifier">PMID</a> <a class="external text" href="http://www.ncbi.nlm.nih.gov/pubmed/4884685" rel="nofollow">4884685</a>. <a class="external free" href="http://www.pubmedcentral.nih.gov/articlerender.fcgi?tool=pmcentrez&artid=225267" rel="nofollow">http://www.pubmedcentral.nih.gov/articlerender.fcgi?tool=pmcentrez&artid=225267</a>. Retrieved 2010-09-03.<span class="Z3988" title="ctx_ver=Z39.88-2004&rft_val_fmt=info%3Aofi%2Ffmt%3Akev%3Amtx%3Ajournal&rft.genre=article&rft.atitle=On+the+conformation+of+transfer+RNA&rft.jtitle=Proc.+Natl.+Acad.+Sci.+U.S.A.&rft.aulast=Cramer+F%2C+Doepner+H%2C+Haar+F+VD%2C+Schlimme+E%2C+Seidel+H&rft.au=Cramer+F%2C+Doepner+H%2C+Haar+F+VD%2C+Schlimme+E%2C+Seidel+H&rft.date=December+1968&rft.volume=61&rft.issue=4&rft.pages=1384%E2%80%9391&rft_id=info:doi/10.1073%2Fpnas.61.4.1384&rft_id=info:pmc/225267&rft_id=info:pmid/4884685&rft_id=http%3A%2F%2Fwww.pubmedcentral.nih.gov%2Farticlerender.fcgi%3Ftool%3Dpmcentrez%26artid%3D225267&rfr_id=info:sid/en.wikipedia.org:Non-coding_RNA"> </li>
<li id="cite_note-14"><a href="#cite_ref-14">^</a> Ladner JE, Jack A, Robertus JD, et al. (November 1975). <a class="external text" href="http://www.pubmedcentral.nih.gov/articlerender.fcgi?tool=pmcentrez&artid=388732" rel="nofollow">"Structure of yeast phenylalanine transfer RNA at 2.5 A resolution"</a>. Proc. Natl. Acad. Sci. U.S.A. 72 (11): 4414–8. <a title="Digital object identifier" href="/wiki/Digital_object_identifier">doi</a>:<a class="external text" href="http://dx.doi.org/10.1073%2Fpnas.72.11.4414" rel="nofollow">10.1073/pnas.72.11.4414</a>. <a title="PubMed Central" href="/wiki/PubMed_Central">PMC</a> <a class="external text" href="http://www.pubmedcentral.gov/articlerender.fcgi?tool=pmcentrez&artid=388732" rel="nofollow">388732</a>. <a class="mw-redirect" title="PubMed Identifier" href="/wiki/PubMed_Identifier">PMID</a> <a class="external text" href="http://www.ncbi.nlm.nih.gov/pubmed/1105583" rel="nofollow">1105583</a>. <a class="external free" href="http://www.pubmedcentral.nih.gov/articlerender.fcgi?tool=pmcentrez&artid=388732" rel="nofollow">http://www.pubmedcentral.nih.gov/articlerender.fcgi?tool=pmcentrez&artid=388732</a>. Retrieved 2010-09-03.<span class="Z3988" title="ctx_ver=Z39.88-2004&rft_val_fmt=info%3Aofi%2Ffmt%3Akev%3Amtx%3Ajournal&rft.genre=article&rft.atitle=Structure+of+yeast+phenylalanine+transfer+RNA+at+2.5+A+resolution&rft.jtitle=Proc.+Natl.+Acad.+Sci.+U.S.A.&rft.aulast=Ladner+JE%2C+Jack+A%2C+Robertus+JD%2C+%27%27et+al.%27%27&rft.au=Ladner+JE%2C+Jack+A%2C+Robertus+JD%2C+%27%27et+al.%27%27&rft.date=November+1975&rft.volume=72&rft.issue=11&rft.pages=4414%E2%80%938&rft_id=info:doi/10.1073%2Fpnas.72.11.4414&rft_id=info:pmc/388732&rft_id=info:pmid/1105583&rft_id=http%3A%2F%2Fwww.pubmedcentral.nih.gov%2Farticlerender.fcgi%3Ftool%3Dpmcentrez%26artid%3D388732&rfr_id=info:sid/en.wikipedia.org:Non-coding_RNA"> </li>
<li id="cite_note-15"><a href="#cite_ref-15">^</a> Kim SH, Quigley GJ, Suddath FL, et al. (1973). "Three-dimensional structure of yeast phenylalanine transfer RNA: folding of the polynucleotide chain". Science 179 (70): 285–8. <a title="Digital object identifier" href="/wiki/Digital_object_identifier">doi</a>:<a class="external text" href="http://dx.doi.org/10.1126%2Fscience.179.4070.285" rel="nofollow">10.1126/science.179.4070.285</a>. <a class="mw-redirect" title="PubMed Identifier" href="/wiki/PubMed_Identifier">PMID</a> <a class="external text" href="http://www.ncbi.nlm.nih.gov/pubmed/4566654" rel="nofollow">4566654</a>.<span class="Z3988" title="ctx_ver=Z39.88-2004&rft_val_fmt=info%3Aofi%2Ffmt%3Akev%3Amtx%3Ajournal&rft.genre=article&rft.atitle=Three-dimensional+structure+of+yeast+phenylalanine+transfer+RNA%3A+folding+of+the+polynucleotide+chain&rft.jtitle=Science&rft.aulast=Kim+SH%2C+Quigley+GJ%2C+Suddath+FL%2C+%27%27et+al.%27%27&rft.au=Kim+SH%2C+Quigley+GJ%2C+Suddath+FL%2C+%27%27et+al.%27%27&rft.date=1973&rft.volume=179&rft.issue=70&rft.pages=285%E2%80%938&rft_id=info:doi/10.1126%2Fscience.179.4070.285&rft_id=info:pmid/4566654&rfr_id=info:sid/en.wikipedia.org:Non-coding_RNA"> </li>
<li id="cite_note-Edd01-16">^ <a href="#cite_ref-Edd01_16-0">a</a> <a href="#cite_ref-Edd01_16-1">b</a> Eddy SR (December 2001). "Non-coding RNA genes and the modern RNA world". Nat. Rev. Genet. 2 (12): 919–29. <a title="Digital object identifier" href="/wiki/Digital_object_identifier">doi</a>:<a class="external text" href="http://dx.doi.org/10.1038%2F35103511" rel="nofollow">10.1038/35103511</a>. <a class="mw-redirect" title="PubMed Identifier" href="/wiki/PubMed_Identifier">PMID</a> <a class="external text" href="http://www.ncbi.nlm.nih.gov/pubmed/11733745" rel="nofollow">11733745</a>.<span class="Z3988" title="ctx_ver=Z39.88-2004&rft_val_fmt=info%3Aofi%2Ffmt%3Akev%3Amtx%3Ajournal&rft.genre=article&rft.atitle=Non-coding+RNA+genes+and+the+modern+RNA+world&rft.jtitle=Nat.+Rev.+Genet.&rft.aulast=Eddy+SR&rft.au=Eddy+SR&rft.date=December+2001&rft.volume=2&rft.issue=12&rft.pages=919%E2%80%9329&rft_id=info:doi/10.1038%2F35103511&rft_id=info:pmid/11733745&rfr_id=info:sid/en.wikipedia.org:Non-coding_RNA"> </li>
<li id="cite_note-17"><a href="#cite_ref-17">^</a> Daneholt, Bertil. <a class="external text" href="http://nobelprize.org/nobel_prizes/medicine/laureates/2006/adv.html" rel="nofollow">"Advanced Information: RNA interference"</a>. The Nobel Prize in Physiology or Medicine 2006. <a class="external free" href="http://nobelprize.org/nobel_prizes/medicine/laureates/2006/adv.html" rel="nofollow">http://nobelprize.org/nobel_prizes/medicine/laureates/2006/adv.html</a>. Retrieved 2007-01-25.<span class="Z3988" title="ctx_ver=Z39.88-2004&rft_val_fmt=info%3Aofi%2Ffmt%3Akev%3Amtx%3Abook&rft.genre=bookitem&rft.btitle=Advanced+Information%3A+RNA+interference&rft.atitle=The+Nobel+Prize+in+Physiology+or+Medicine+2006&rft.aulast=Daneholt&rft.aufirst=Bertil&rft.au=Daneholt%2C%26%2332%3BBertil&rft_id=http%3A%2F%2Fnobelprize.org%2Fnobel_prizes%2Fmedicine%2Flaureates%2F2006%2Fadv.html&rfr_id=info:sid/en.wikipedia.org:Non-coding_RNA"> </li>
<li id="cite_note-pmid9419222-18"><a href="#cite_ref-pmid9419222_18-0">^</a> Jeffares DC, Poole AM, Penny D (1998). "Relics from the RNA world.". J Mol Evol 46 (1): 18–36. <a title="Digital object identifier" href="/wiki/Digital_object_identifier">doi</a>:<a class="external text" href="http://dx.doi.org/10.1007%2FPL00006280" rel="nofollow">10.1007/PL00006280</a>. <a class="mw-redirect" title="PubMed Identifier" href="/wiki/PubMed_Identifier">PMID</a> <a class="external text" href="http://www.ncbi.nlm.nih.gov/pubmed/9419222" rel="nofollow">9419222</a>.<span class="Z3988" title="ctx_ver=Z39.88-2004&rft_val_fmt=info%3Aofi%2Ffmt%3Akev%3Amtx%3Ajournal&rft.genre=article&rft.atitle=Relics+from+the+RNA+world.&rft.jtitle=J+Mol+Evol&rft.aulast=Jeffares+DC%2C+Poole+AM%2C+Penny+D&rft.au=Jeffares+DC%2C+Poole+AM%2C+Penny+D&rft.date=1998&rft.volume=46&rft.issue=1&rft.pages=18%E2%80%9336&rft_id=info:doi/10.1007%2FPL00006280&rft_id=info:pmid/9419222&rfr_id=info:sid/en.wikipedia.org:Non-coding_RNA"> </li>
<li id="cite_note-pmid9419221-19"><a href="#cite_ref-pmid9419221_19-0">^</a> Poole AM, Jeffares DC, Penny D (1998). "The path from the RNA world.". J Mol Evol 46 (1): 1–17. <a title="Digital object identifier" href="/wiki/Digital_object_identifier">doi</a>:<a class="external text" href="http://dx.doi.org/10.1007%2FPL00006275" rel="nofollow">10.1007/PL00006275</a>. <a class="mw-redirect" title="PubMed Identifier" href="/wiki/PubMed_Identifier">PMID</a> <a class="external text" href="http://www.ncbi.nlm.nih.gov/pubmed/9419221" rel="nofollow">9419221</a>.<span class="Z3988" title="ctx_ver=Z39.88-2004&rft_val_fmt=info%3Aofi%2Ffmt%3Akev%3Amtx%3Ajournal&rft.genre=article&rft.atitle=The+path+from+the+RNA+world.&rft.jtitle=J+Mol+Evol&rft.aulast=Poole+AM%2C+Jeffares+DC%2C+Penny+D&rft.au=Poole+AM%2C+Jeffares+DC%2C+Penny+D&rft.date=1998&rft.volume=46&rft.issue=1&rft.pages=1%E2%80%9317&rft_id=info:doi/10.1007%2FPL00006275&rft_id=info:pmid/9419221&rfr_id=info:sid/en.wikipedia.org:Non-coding_RNA"> </li>
<li id="cite_note-pmid10497339-20"><a href="#cite_ref-pmid10497339_20-0">^</a> Poole A, Jeffares D, Penny D (1999). "Early evolution: prokaryotes, the new kids on the block.". Bioessays 21 (10): 880–9. <a title="Digital object identifier" href="/wiki/Digital_object_identifier">doi</a>:<a class="external text" href="http://dx.doi.org/10.1002%2F%28SICI%291521-1878%28199910%2921%3A10%3C880%3A%3AAID-BIES11%3E3.0.CO%3B2-P" rel="nofollow">10.1002/(SICI)1521-1878(199910)21:10<880::AID-BIES11>3.0.CO;2-P</a>. <a class="mw-redirect" title="PubMed Identifier" href="/wiki/PubMed_Identifier">PMID</a> <a class="external text" href="http://www.ncbi.nlm.nih.gov/pubmed/10497339" rel="nofollow">10497339</a>.<span class="Z3988" title="ctx_ver=Z39.88-2004&rft_val_fmt=info%3Aofi%2Ffmt%3Akev%3Amtx%3Ajournal&rft.genre=article&rft.atitle=Early+evolution%3A+prokaryotes%2C+the+new+kids+on+the+block.&rft.jtitle=Bioessays&rft.aulast=Poole+A%2C+Jeffares+D%2C+Penny+D&rft.au=Poole+A%2C+Jeffares+D%2C+Penny+D&rft.date=1999&rft.volume=21&rft.issue=10&rft.pages=880%E2%80%939&rft_id=info:doi/10.1002%2F%28SICI%291521-1878%28199910%2921%3A10%3C880%3A%3AAID-BIES11%3E3.0.CO%3B2-P&rft_id=info:pmid/10497339&rfr_id=info:sid/en.wikipedia.org:Non-coding_RNA"> </li>
<li id="cite_note-Ban-21"><a href="#cite_ref-Ban_21-0">^</a> Ban N, Nissen P, Hansen J, Moore P, Steitz T (2000). "The complete atomic structure of the large ribosomal subunit at 2.4 ångström resolution". Science 289 (5481): 905–20. <a title="Digital object identifier" href="/wiki/Digital_object_identifier">doi</a>:<a class="external text" href="http://dx.doi.org/10.1126%2Fscience.289.5481.905" rel="nofollow">10.1126/science.289.5481.905</a>. <a class="mw-redirect" title="PubMed Identifier" href="/wiki/PubMed_Identifier">PMID</a> <a class="external text" href="http://www.ncbi.nlm.nih.gov/pubmed/10937989" rel="nofollow">10937989</a>.<span class="Z3988" title="ctx_ver=Z39.88-2004&rft_val_fmt=info%3Aofi%2Ffmt%3Akev%3Amtx%3Ajournal&rft.genre=article&rft.atitle=The+complete+atomic+structure+of+the+large+ribosomal+subunit+at+2.4+%C3%A5ngstr%C3%B6m+resolution&rft.jtitle=Science&rft.aulast=Ban+N%2C+Nissen+P%2C+Hansen+J%2C+Moore+P%2C+Steitz+T&rft.au=Ban+N%2C+Nissen+P%2C+Hansen+J%2C+Moore+P%2C+Steitz+T&rft.date=2000&rft.volume=289&rft.issue=5481&rft.pages=905%E2%80%9320&rft_id=info:doi/10.1126%2Fscience.289.5481.905&rft_id=info:pmid/10937989&rfr_id=info:sid/en.wikipedia.org:Non-coding_RNA"> </li>
<li id="cite_note-PMID16540690-22"><a href="#cite_ref-PMID16540690_22-0">^</a> Zhu Y, Stribinskis V, Ramos KS, Li Y (2006). <a class="external text" href="http://www.pubmedcentral.nih.gov/articlerender.fcgi?tool=pmcentrez&artid=1440897" rel="nofollow">"Sequence analysis of RNase MRP RNA reveals its origination from eukaryotic RNase P RNA"</a>. RNA 12 (5): 699–706. <a title="Digital object identifier" href="/wiki/Digital_object_identifier">doi</a>:<a class="external text" href="http://dx.doi.org/10.1261%2Frna.2284906" rel="nofollow">10.1261/rna.2284906</a>. <a title="PubMed Central" href="/wiki/PubMed_Central">PMC</a> <a class="external text" href="http://www.pubmedcentral.gov/articlerender.fcgi?tool=pmcentrez&artid=1440897" rel="nofollow">1440897</a>. <a class="mw-redirect" title="PubMed Identifier" href="/wiki/PubMed_Identifier">PMID</a> <a class="external text" href="http://www.ncbi.nlm.nih.gov/pubmed/16540690" rel="nofollow">16540690</a>. <a class="external free" href="http://www.pubmedcentral.nih.gov/articlerender.fcgi?tool=pmcentrez&artid=1440897" rel="nofollow">http://www.pubmedcentral.nih.gov/articlerender.fcgi?tool=pmcentrez&artid=1440897</a>.<span class="Z3988" title="ctx_ver=Z39.88-2004&rft_val_fmt=info%3Aofi%2Ffmt%3Akev%3Amtx%3Ajournal&rft.genre=article&rft.atitle=Sequence+analysis+of+RNase+MRP+RNA+reveals+its+origination+from+eukaryotic+RNase+P+RNA&rft.jtitle=RNA&rft.aulast=Zhu+Y%2C+Stribinskis+V%2C+Ramos+KS%2C+Li+Y&rft.au=Zhu+Y%2C+Stribinskis+V%2C+Ramos+KS%2C+Li+Y&rft.date=2006&rft.volume=12&rft.issue=5&rft.pages=699%E2%80%93706&rft_id=info:doi/10.1261%2Frna.2284906&rft_id=info:pmc/1440897&rft_id=info:pmid/16540690&rft_id=http%3A%2F%2Fwww.pubmedcentral.nih.gov%2Farticlerender.fcgi%3Ftool%3Dpmcentrez%26artid%3D1440897&rfr_id=info:sid/en.wikipedia.org:Non-coding_RNA"> </li>
<li id="cite_note-Kishore-23"><a href="#cite_ref-Kishore_23-0">^</a> Kishore S, Stamm S (2006). "The snoRNA HBII-52 regulates alternative splicing of the serotonin receptor 2C". Science 311 (5758): 230–231. <a title="Digital object identifier" href="/wiki/Digital_object_identifier">doi</a>:<a class="external text" href="http://dx.doi.org/10.1126%2Fscience.1118265" rel="nofollow">10.1126/science.1118265</a>. <a class="mw-redirect" title="PubMed Identifier" href="/wiki/PubMed_Identifier">PMID</a> <a class="external text" href="http://www.ncbi.nlm.nih.gov/pubmed/16357227" rel="nofollow">16357227</a>.<span class="Z3988" title="ctx_ver=Z39.88-2004&rft_val_fmt=info%3Aofi%2Ffmt%3Akev%3Amtx%3Ajournal&rft.genre=article&rft.atitle=The+snoRNA+HBII-52+regulates+alternative+splicing+of+the+serotonin+receptor+2C&rft.jtitle=Science&rft.aulast=Kishore+S%2C+Stamm+S&rft.au=Kishore+S%2C+Stamm+S&rft.date=2006&rft.volume=311&rft.issue=5758&rft.pages=230%E2%80%93231&rft_id=info:doi/10.1126%2Fscience.1118265&rft_id=info:pmid/16357227&rfr_id=info:sid/en.wikipedia.org:Non-coding_RNA"> </li>
<li id="cite_note-pmid16778078-24"><a href="#cite_ref-pmid16778078_24-0">^</a> Reiner R, Ben-Asouli Y, Krilovetzky I, Jarrous N (2006). <a class="external text" href="http://www.pubmedcentral.nih.gov/articlerender.fcgi?tool=pmcentrez&artid=1482482" rel="nofollow">"A role for the catalytic ribonucleoprotein RNase P in RNA polymerase III transcription."</a>. Genes Dev 20 (12): 1621–35. <a title="Digital object identifier" href="/wiki/Digital_object_identifier">doi</a>:<a class="external text" href="http://dx.doi.org/10.1101%2Fgad.386706" rel="nofollow">10.1101/gad.386706</a>. <a title="PubMed Central" href="/wiki/PubMed_Central">PMC</a> <a class="external text" href="http://www.pubmedcentral.gov/articlerender.fcgi?tool=pmcentrez&artid=1482482" rel="nofollow">1482482</a>. <a class="mw-redirect" title="PubMed Identifier" href="/wiki/PubMed_Identifier">PMID</a> <a class="external text" href="http://www.ncbi.nlm.nih.gov/pubmed/16778078" rel="nofollow">16778078</a>. <a class="external free" href="http://www.pubmedcentral.nih.gov/articlerender.fcgi?tool=pmcentrez&artid=1482482" rel="nofollow">http://www.pubmedcentral.nih.gov/articlerender.fcgi?tool=pmcentrez&artid=1482482</a>.<span class="Z3988" title="ctx_ver=Z39.88-2004&rft_val_fmt=info%3Aofi%2Ffmt%3Akev%3Amtx%3Ajournal&rft.genre=article&rft.atitle=A+role+for+the+catalytic+ribonucleoprotein+RNase+P+in+RNA+polymerase+III+transcription.&rft.jtitle=Genes+Dev&rft.aulast=Reiner+R%2C+Ben-Asouli+Y%2C+Krilovetzky+I%2C+Jarrous+N&rft.au=Reiner+R%2C+Ben-Asouli+Y%2C+Krilovetzky+I%2C+Jarrous+N&rft.date=2006&rft.volume=20&rft.issue=12&rft.pages=1621%E2%80%9335&rft_id=info:doi/10.1101%2Fgad.386706&rft_id=info:pmc/1482482&rft_id=info:pmid/16778078&rft_id=http%3A%2F%2Fwww.pubmedcentral.nih.gov%2Farticlerender.fcgi%3Ftool%3Dpmcentrez%26artid%3D1482482&rfr_id=info:sid/en.wikipedia.org:Non-coding_RNA"> </li>
<li id="cite_note-pmid15300239-25"><a href="#cite_ref-pmid15300239_25-0">^</a> Espinoza CA, Allen TA, Hieb AR, Kugel JF, Goodrich JA (2004). "B2 RNA binds directly to RNA polymerase II to repress transcript synthesis.". Nat Struct Mol Biol 11 (9): 822–9. <a title="Digital object identifier" href="/wiki/Digital_object_identifier">doi</a>:<a class="external text" href="http://dx.doi.org/10.1038%2Fnsmb812" rel="nofollow">10.1038/nsmb812</a>. <a class="mw-redirect" title="PubMed Identifier" href="/wiki/PubMed_Identifier">PMID</a> <a class="external text" href="http://www.ncbi.nlm.nih.gov/pubmed/15300239" rel="nofollow">15300239</a>.<span class="Z3988" title="ctx_ver=Z39.88-2004&rft_val_fmt=info%3Aofi%2Ffmt%3Akev%3Amtx%3Ajournal&rft.genre=article&rft.atitle=B2+RNA+binds+directly+to+RNA+polymerase+II+to+repress+transcript+synthesis.&rft.jtitle=Nat+Struct+Mol+Biol&rft.aulast=Espinoza+CA%2C+Allen+TA%2C+Hieb+AR%2C+Kugel+JF%2C+Goodrich+JA&rft.au=Espinoza+CA%2C+Allen+TA%2C+Hieb+AR%2C+Kugel+JF%2C+Goodrich+JA&rft.date=2004&rft.volume=11&rft.issue=9&rft.pages=822%E2%80%939&rft_id=info:doi/10.1038%2Fnsmb812&rft_id=info:pmid/15300239&rfr_id=info:sid/en.wikipedia.org:Non-coding_RNA"> </li>
<li id="cite_note-pmid18820678-26"><a href="#cite_ref-pmid18820678_26-0">^</a> Hirota K, Miyoshi T, Kugou K, Hoffman CS, Shibata T, Ohta K (2008). "Stepwise chromatin remodelling by a cascade of transcription initiation of non-coding RNAs.". Nature 456 (7218): 130–4. <a title="Digital object identifier" href="/wiki/Digital_object_identifier">doi</a>:<a class="external text" href="http://dx.doi.org/10.1038%2Fnature07348" rel="nofollow">10.1038/nature07348</a>. <a class="mw-redirect" title="PubMed Identifier" href="/wiki/PubMed_Identifier">PMID</a> <a class="external text" href="http://www.ncbi.nlm.nih.gov/pubmed/18820678" rel="nofollow">18820678</a>.<span class="Z3988" title="ctx_ver=Z39.88-2004&rft_val_fmt=info%3Aofi%2Ffmt%3Akev%3Amtx%3Ajournal&rft.genre=article&rft.atitle=Stepwise+chromatin+remodelling+by+a+cascade+of+transcription+initiation+of+non-coding+RNAs.&rft.jtitle=Nature&rft.aulast=Hirota+K%2C+Miyoshi+T%2C+Kugou+K%2C+Hoffman+CS%2C+Shibata+T%2C+Ohta+K&rft.au=Hirota+K%2C+Miyoshi+T%2C+Kugou+K%2C+Hoffman+CS%2C+Shibata+T%2C+Ohta+K&rft.date=2008&rft.volume=456&rft.issue=7218&rft.pages=130%E2%80%934&rft_id=info:doi/10.1038%2Fnature07348&rft_id=info:pmid/18820678&rfr_id=info:sid/en.wikipedia.org:Non-coding_RNA"> </li>
<li id="cite_note-pmid12446910-27"><a href="#cite_ref-pmid12446910_27-0">^</a> Park Y, Kelley RL, Oh H, Kuroda MI, Meller VH (2002). "Extent of chromatin spreading determined by roX RNA recruitment of MSL proteins.". Science 298 (5598): 1620–3. <a title="Digital object identifier" href="/wiki/Digital_object_identifier">doi</a>:<a class="external text" href="http://dx.doi.org/10.1126%2Fscience.1076686" rel="nofollow">10.1126/science.1076686</a>. <a class="mw-redirect" title="PubMed Identifier" href="/wiki/PubMed_Identifier">PMID</a> <a class="external text" href="http://www.ncbi.nlm.nih.gov/pubmed/12446910" rel="nofollow">12446910</a>.<span class="Z3988" title="ctx_ver=Z39.88-2004&rft_val_fmt=info%3Aofi%2Ffmt%3Akev%3Amtx%3Ajournal&rft.genre=article&rft.atitle=Extent+of+chromatin+spreading+determined+by+roX+RNA+recruitment+of+MSL+proteins.&rft.jtitle=Science&rft.aulast=Park+Y%2C+Kelley+RL%2C+Oh+H%2C+Kuroda+MI%2C+Meller+VH&rft.au=Park+Y%2C+Kelley+RL%2C+Oh+H%2C+Kuroda+MI%2C+Meller+VH&rft.date=2002&rft.volume=298&rft.issue=5598&rft.pages=1620%E2%80%933&rft_id=info:doi/10.1126%2Fscience.1076686&rft_id=info:pmid/12446910&rfr_id=info:sid/en.wikipedia.org:Non-coding_RNA"> </li>
<li id="cite_note-pmid18042713-28"><a href="#cite_ref-pmid18042713_28-0">^</a> Wadler CS, Vanderpool CK (2007). <a class="external text" href="http://www.pubmedcentral.nih.gov/articlerender.fcgi?tool=pmcentrez&artid=2154452" rel="nofollow">"A dual function for a bacterial small RNA: SgrS performs base pairing-dependent regulation and encodes a functional polypeptide."</a>. Proc Natl Acad Sci USA 104 (51): 20454–9. <a title="Digital object identifier" href="/wiki/Digital_object_identifier">doi</a>:<a class="external text" href="http://dx.doi.org/10.1073%2Fpnas.0708102104" rel="nofollow">10.1073/pnas.0708102104</a>. <a title="PubMed Central" href="/wiki/PubMed_Central">PMC</a> <a class="external text" href="http://www.pubmedcentral.gov/articlerender.fcgi?tool=pmcentrez&artid=2154452" rel="nofollow">2154452</a>. <a class="mw-redirect" title="PubMed Identifier" href="/wiki/PubMed_Identifier">PMID</a> <a class="external text" href="http://www.ncbi.nlm.nih.gov/pubmed/18042713" rel="nofollow">18042713</a>. <a class="external free" href="http://www.pubmedcentral.nih.gov/articlerender.fcgi?tool=pmcentrez&artid=2154452" rel="nofollow">http://www.pubmedcentral.nih.gov/articlerender.fcgi?tool=pmcentrez&artid=2154452</a>.<span class="Z3988" title="ctx_ver=Z39.88-2004&rft_val_fmt=info%3Aofi%2Ffmt%3Akev%3Amtx%3Ajournal&rft.genre=article&rft.atitle=A+dual+function+for+a+bacterial+small+RNA%3A+SgrS+performs+base+pairing-dependent+regulation+and+encodes+a+functional+polypeptide.&rft.jtitle=Proc+Natl+Acad+Sci+USA&rft.aulast=Wadler+CS%2C+Vanderpool+CK&rft.au=Wadler+CS%2C+Vanderpool+CK&rft.date=2007&rft.volume=104&rft.issue=51&rft.pages=20454%E2%80%939&rft_id=info:doi/10.1073%2Fpnas.0708102104&rft_id=info:pmc/2154452&rft_id=info:pmid/18042713&rft_id=http%3A%2F%2Fwww.pubmedcentral.nih.gov%2Farticlerender.fcgi%3Ftool%3Dpmcentrez%26artid%3D2154452&rfr_id=info:sid/en.wikipedia.org:Non-coding_RNA"> </li>
<li id="cite_note-pmid19043537-29"><a href="#cite_ref-pmid19043537_29-0">^</a> Dinger ME, Pang KC, Mercer TR, Mattick JS (2008). <a class="external text" href="http://www.pubmedcentral.nih.gov/articlerender.fcgi?tool=pmcentrez&artid=2518207" rel="nofollow">"Differentiating protein-coding and noncoding RNA: challenges and ambiguities."</a>. PLoS Comput Biol 4 (11): e1000176. <a title="Digital object identifier" href="/wiki/Digital_object_identifier">doi</a>:<a class="external text" href="http://dx.doi.org/10.1371%2Fjournal.pcbi.1000176" rel="nofollow">10.1371/journal.pcbi.1000176</a>. <a title="PubMed Central" href="/wiki/PubMed_Central">PMC</a> <a class="external text" href="http://www.pubmedcentral.gov/articlerender.fcgi?tool=pmcentrez&artid=2518207" rel="nofollow">2518207</a>. <a class="mw-redirect" title="PubMed Identifier" href="/wiki/PubMed_Identifier">PMID</a> <a class="external text" href="http://www.ncbi.nlm.nih.gov/pubmed/19043537" rel="nofollow">19043537</a>. <a class="external free" href="http://www.pubmedcentral.nih.gov/articlerender.fcgi?tool=pmcentrez&artid=2518207" rel="nofollow">http://www.pubmedcentral.nih.gov/articlerender.fcgi?tool=pmcentrez&artid=2518207</a>.<span class="Z3988" title="ctx_ver=Z39.88-2004&rft_val_fmt=info%3Aofi%2Ffmt%3Akev%3Amtx%3Ajournal&rft.genre=article&rft.atitle=Differentiating+protein-coding+and+noncoding+RNA%3A+challenges+and+ambiguities.&rft.jtitle=PLoS+Comput+Biol&rft.aulast=Dinger+ME%2C+Pang+KC%2C+Mercer+TR%2C+Mattick+JS&rft.au=Dinger+ME%2C+Pang+KC%2C+Mercer+TR%2C+Mattick+JS&rft.date=2008&rft.volume=4&rft.issue=11&rft.pages=e1000176&rft_id=info:doi/10.1371%2Fjournal.pcbi.1000176&rft_id=info:pmc/2518207&rft_id=info:pmid/19043537&rft_id=http%3A%2F%2Fwww.pubmedcentral.nih.gov%2Farticlerender.fcgi%3Ftool%3Dpmcentrez%26artid%3D2518207&rfr_id=info:sid/en.wikipedia.org:Non-coding_RNA"> </li>
<li id="cite_note-pmid19043559-30"><a href="#cite_ref-pmid19043559_30-0">^</a> Saraiya AA, Wang CC (2008). <a class="external text" href="http://www.pubmedcentral.nih.gov/articlerender.fcgi?tool=pmcentrez&artid=2583053" rel="nofollow">"snoRNA, a novel precursor of microRNA in Giardia lamblia."</a>. PLoS Pathog 4 (11): e1000224. <a title="Digital object identifier" href="/wiki/Digital_object_identifier">doi</a>:<a class="external text" href="http://dx.doi.org/10.1371%2Fjournal.ppat.1000224" rel="nofollow">10.1371/journal.ppat.1000224</a>. <a title="PubMed Central" href="/wiki/PubMed_Central">PMC</a> <a class="external text" href="http://www.pubmedcentral.gov/articlerender.fcgi?tool=pmcentrez&artid=2583053" rel="nofollow">2583053</a>. <a class="mw-redirect" title="PubMed Identifier" href="/wiki/PubMed_Identifier">PMID</a> <a class="external text" href="http://www.ncbi.nlm.nih.gov/pubmed/19043559" rel="nofollow">19043559</a>. <a class="external free" href="http://www.pubmedcentral.nih.gov/articlerender.fcgi?tool=pmcentrez&artid=2583053" rel="nofollow">http://www.pubmedcentral.nih.gov/articlerender.fcgi?tool=pmcentrez&artid=2583053</a>.<span class="Z3988" title="ctx_ver=Z39.88-2004&rft_val_fmt=info%3Aofi%2Ffmt%3Akev%3Amtx%3Ajournal&rft.genre=article&rft.atitle=snoRNA%2C+a+novel+precursor+of+microRNA+in+Giardia+lamblia.&rft.jtitle=PLoS+Pathog&rft.aulast=Saraiya+AA%2C+Wang+CC&rft.au=Saraiya+AA%2C+Wang+CC&rft.date=2008&rft.volume=4&rft.issue=11&rft.pages=e1000224&rft_id=info:doi/10.1371%2Fjournal.ppat.1000224&rft_id=info:pmc/2583053&rft_id=info:pmid/19043559&rft_id=http%3A%2F%2Fwww.pubmedcentral.nih.gov%2Farticlerender.fcgi%3Ftool%3Dpmcentrez%26artid%3D2583053&rfr_id=info:sid/en.wikipedia.org:Non-coding_RNA"> </li>
<li id="cite_note-pmid19026782-31"><a href="#cite_ref-pmid19026782_31-0">^</a> Ender C, Krek A, Friedländer MR, Beitzinger M, Weinmann L, Chen W, Pfeffer S, Rajewsky N, Meister G (2008). "A human snoRNA with microRNA-like functions.". Mol Cell 32 (4): 519–28. <a title="Digital object identifier" href="/wiki/Digital_object_identifier">doi</a>:<a class="external text" href="http://dx.doi.org/10.1016%2Fj.molcel.2008.10.017" rel="nofollow">10.1016/j.molcel.2008.10.017</a>. <a class="mw-redirect" title="PubMed Identifier" href="/wiki/PubMed_Identifier">PMID</a> <a class="external text" href="http://www.ncbi.nlm.nih.gov/pubmed/19026782" rel="nofollow">19026782</a>.<span class="Z3988" title="ctx_ver=Z39.88-2004&rft_val_fmt=info%3Aofi%2Ffmt%3Akev%3Amtx%3Ajournal&rft.genre=article&rft.atitle=A+human+snoRNA+with+microRNA-like+functions.&rft.jtitle=Mol+Cell&rft.aulast=Ender+C%2C+Krek+A%2C+Friedl%C3%A4nder+MR%2C+Beitzinger+M%2C+Weinmann+L%2C+Chen+W%2C+Pfeffer+S%2C+Rajewsky+N%2C+Meister+G&rft.au=Ender+C%2C+Krek+A%2C+Friedl%C3%A4nder+MR%2C+Beitzinger+M%2C+Weinmann+L%2C+Chen+W%2C+Pfeffer+S%2C+Rajewsky+N%2C+Meister+G&rft.date=2008&rft.volume=32&rft.issue=4&rft.pages=519%E2%80%9328&rft_id=info:doi/10.1016%2Fj.molcel.2008.10.017&rft_id=info:pmid/19026782&rfr_id=info:sid/en.wikipedia.org:Non-coding_RNA"> </li>
<li id="cite_note-pmid17710122-32"><a href="#cite_ref-pmid17710122_32-0">^</a> Leygue E (2007). <a class="external text" href="http://www.pubmedcentral.nih.gov/articlerender.fcgi?tool=pmcentrez&artid=1948073" rel="nofollow">"Steroid receptor RNA activator (SRA1): unusual bifaceted gene products with suspected relevance to breast cancer."</a>. Nucl Recept Signal 5: e006. <a title="Digital object identifier" href="/wiki/Digital_object_identifier">doi</a>:<a class="external text" href="http://dx.doi.org/10.1621%2Fnrs.05006" rel="nofollow">10.1621/nrs.05006</a>. <a title="PubMed Central" href="/wiki/PubMed_Central">PMC</a> <a class="external text" href="http://www.pubmedcentral.gov/articlerender.fcgi?tool=pmcentrez&artid=1948073" rel="nofollow">1948073</a>. <a class="mw-redirect" title="PubMed Identifier" href="/wiki/PubMed_Identifier">PMID</a> <a class="external text" href="http://www.ncbi.nlm.nih.gov/pubmed/17710122" rel="nofollow">17710122</a>. <a class="external free" href="http://www.pubmedcentral.nih.gov/articlerender.fcgi?tool=pmcentrez&artid=1948073" rel="nofollow">http://www.pubmedcentral.nih.gov/articlerender.fcgi?tool=pmcentrez&artid=1948073</a>.<span class="Z3988" title="ctx_ver=Z39.88-2004&rft_val_fmt=info%3Aofi%2Ffmt%3Akev%3Amtx%3Ajournal&rft.genre=article&rft.atitle=Steroid+receptor+RNA+activator+%28SRA1%29%3A+unusual+bifaceted+gene+products+with+suspected+relevance+to+breast+cancer.&rft.jtitle=Nucl+Recept+Signal&rft.aulast=Leygue+E&rft.au=Leygue+E&rft.date=2007&rft.volume=5&rft.pages=e006&rft_id=info:doi/10.1621%2Fnrs.05006&rft_id=info:pmc/1948073&rft_id=info:pmid/17710122&rft_id=http%3A%2F%2Fwww.pubmedcentral.nih.gov%2Farticlerender.fcgi%3Ftool%3Dpmcentrez%26artid%3D1948073&rfr_id=info:sid/en.wikipedia.org:Non-coding_RNA"> </li>
<li id="cite_note-pmid9012531-33"><a href="#cite_ref-pmid9012531_33-0">^</a> Zhang J, King ML (1996). "Xenopus VegT RNA is localized to the vegetal cortex during oogenesis and encodes a novel T-box transcription factor involved in mesodermal patterning.". Development 122 (12): 4119–29. <a class="mw-redirect" title="PubMed Identifier" href="/wiki/PubMed_Identifier">PMID</a> <a class="external text" href="http://www.ncbi.nlm.nih.gov/pubmed/9012531" rel="nofollow">9012531</a>.<span class="Z3988" title="ctx_ver=Z39.88-2004&rft_val_fmt=info%3Aofi%2Ffmt%3Akev%3Amtx%3Ajournal&rft.genre=article&rft.atitle=Xenopus+VegT+RNA+is+localized+to+the+vegetal+cortex+during+oogenesis+and+encodes+a+novel+T-box+transcription+factor+involved+in+mesodermal+patterning.&rft.jtitle=Development&rft.aulast=Zhang+J%2C+King+ML&rft.au=Zhang+J%2C+King+ML&rft.date=1996&rft.volume=122&rft.issue=12&rft.pages=4119%E2%80%9329&rft_id=info:pmid/9012531&rfr_id=info:sid/en.wikipedia.org:Non-coding_RNA"> </li>
<li id="cite_note-pmid16000384-34"><a href="#cite_ref-pmid16000384_34-0">^</a> Kloc M, Wilk K, Vargas D, Shirato Y, Bilinski S, Etkin LD (2005). "Potential structural role of non-coding and coding RNAs in the organization of the cytoskeleton at the vegetal cortex of Xenopus oocytes.". Development 132 (15): 3445–57. <a title="Digital object identifier" href="/wiki/Digital_object_identifier">doi</a>:<a class="external text" href="http://dx.doi.org/10.1242%2Fdev.01919" rel="nofollow">10.1242/dev.01919</a>. <a class="mw-redirect" title="PubMed Identifier" href="/wiki/PubMed_Identifier">PMID</a> <a class="external text" href="http://www.ncbi.nlm.nih.gov/pubmed/16000384" rel="nofollow">16000384</a>.<span class="Z3988" title="ctx_ver=Z39.88-2004&rft_val_fmt=info%3Aofi%2Ffmt%3Akev%3Amtx%3Ajournal&rft.genre=article&rft.atitle=Potential+structural+role+of+non-coding+and+coding+RNAs+in+the+organization+of+the+cytoskeleton+at+the+vegetal+cortex+of+Xenopus+oocytes.&rft.jtitle=Development&rft.aulast=Kloc+M%2C+Wilk+K%2C+Vargas+D%2C+Shirato+Y%2C+Bilinski+S%2C+Etkin+LD&rft.au=Kloc+M%2C+Wilk+K%2C+Vargas+D%2C+Shirato+Y%2C+Bilinski+S%2C+Etkin+LD&rft.date=2005&rft.volume=132&rft.issue=15&rft.pages=3445%E2%80%9357&rft_id=info:doi/10.1242%2Fdev.01919&rft_id=info:pmid/16000384&rfr_id=info:sid/en.wikipedia.org:Non-coding_RNA"> </li>
<li id="cite_note-pmid16835436-35"><a href="#cite_ref-pmid16835436_35-0">^</a> Jenny A, Hachet O, Závorszky P, Cyrklaff A, Weston MD, Johnston DS, Erdélyi M, Ephrussi A (2006). "A translation-independent role of oskar RNA in early Drosophila oogenesis.". Development 133 (15): 2827–33. <a title="Digital object identifier" href="/wiki/Digital_object_identifier">doi</a>:<a class="external text" href="http://dx.doi.org/10.1242%2Fdev.02456" rel="nofollow">10.1242/dev.02456</a>. <a class="mw-redirect" title="PubMed Identifier" href="/wiki/PubMed_Identifier">PMID</a> <a class="external text" href="http://www.ncbi.nlm.nih.gov/pubmed/16835436" rel="nofollow">16835436</a>.<span class="Z3988" title="ctx_ver=Z39.88-2004&rft_val_fmt=info%3Aofi%2Ffmt%3Akev%3Amtx%3Ajournal&rft.genre=article&rft.atitle=A+translation-independent+role+of+oskar+RNA+in+early+Drosophila+oogenesis.&rft.jtitle=Development&rft.aulast=Jenny+A%2C+Hachet+O%2C+Z%C3%A1vorszky+P%2C+Cyrklaff+A%2C+Weston+MD%2C+Johnston+DS%2C+Erd%C3%A9lyi+M%2C+Ephrussi+A&rft.au=Jenny+A%2C+Hachet+O%2C+Z%C3%A1vorszky+P%2C+Cyrklaff+A%2C+Weston+MD%2C+Johnston+DS%2C+Erd%C3%A9lyi+M%2C+Ephrussi+A&rft.date=2006&rft.volume=133&rft.issue=15&rft.pages=2827%E2%80%9333&rft_id=info:doi/10.1242%2Fdev.02456&rft_id=info:pmid/16835436&rfr_id=info:sid/en.wikipedia.org:Non-coding_RNA"> </li>
<li id="cite_note-pmid17452360-36"><a href="#cite_ref-pmid17452360_36-0">^</a> Gultyaev AP, Roussis A (2007). <a class="external text" href="http://www.pubmedcentral.nih.gov/articlerender.fcgi?tool=pmcentrez&artid=1888808" rel="nofollow">"Identification of conserved secondary structures and expansion segments in enod40 RNAs reveals new enod40 homologues in plants."</a>. Nucleic Acids Res 35 (9): 3144–52. <a title="Digital object identifier" href="/wiki/Digital_object_identifier">doi</a>:<a class="external text" href="http://dx.doi.org/10.1093%2Fnar%2Fgkm173" rel="nofollow">10.1093/nar/gkm173</a>. <a title="PubMed Central" href="/wiki/PubMed_Central">PMC</a> <a class="external text" href="http://www.pubmedcentral.gov/articlerender.fcgi?tool=pmcentrez&artid=1888808" rel="nofollow">1888808</a>. <a class="mw-redirect" title="PubMed Identifier" href="/wiki/PubMed_Identifier">PMID</a> <a class="external text" href="http://www.ncbi.nlm.nih.gov/pubmed/17452360" rel="nofollow">17452360</a>. <a class="external free" href="http://www.pubmedcentral.nih.gov/articlerender.fcgi?tool=pmcentrez&artid=1888808" rel="nofollow">http://www.pubmedcentral.nih.gov/articlerender.fcgi?tool=pmcentrez&artid=1888808</a>.<span class="Z3988" title="ctx_ver=Z39.88-2004&rft_val_fmt=info%3Aofi%2Ffmt%3Akev%3Amtx%3Ajournal&rft.genre=article&rft.atitle=Identification+of+conserved+secondary+structures+and+expansion+segments+in+enod40+RNAs+reveals+new+enod40+homologues+in+plants.&rft.jtitle=Nucleic+Acids+Res&rft.aulast=Gultyaev+AP%2C+Roussis+A&rft.au=Gultyaev+AP%2C+Roussis+A&rft.date=2007&rft.volume=35&rft.issue=9&rft.pages=3144%E2%80%9352&rft_id=info:doi/10.1093%2Fnar%2Fgkm173&rft_id=info:pmc/1888808&rft_id=info:pmid/17452360&rft_id=http%3A%2F%2Fwww.pubmedcentral.nih.gov%2Farticlerender.fcgi%3Ftool%3Dpmcentrez%26artid%3D1888808&rfr_id=info:sid/en.wikipedia.org:Non-coding_RNA"> </li>
<li id="cite_note-pmid15944708-37"><a href="#cite_ref-pmid15944708_37-0">^</a> Lu J, Getz G, Miska EA, Alvarez-Saavedra E, Lamb J, Peck D, Sweet-Cordero A, Ebert BL, Mak RH, Ferrando AA, Downing JR, Jacks T, Horvitz HR, Golub TR (2005). "MicroRNA expression profiles classify human cancers". Nature 435 (7043): 834–8. <a title="Digital object identifier" href="/wiki/Digital_object_identifier">doi</a>:<a class="external text" href="http://dx.doi.org/10.1038%2Fnature03702" rel="nofollow">10.1038/nature03702</a>. <a class="mw-redirect" title="PubMed Identifier" href="/wiki/PubMed_Identifier">PMID</a> <a class="external text" href="http://www.ncbi.nlm.nih.gov/pubmed/15944708" rel="nofollow">15944708</a>.<span class="Z3988" title="ctx_ver=Z39.88-2004&rft_val_fmt=info%3Aofi%2Ffmt%3Akev%3Amtx%3Ajournal&rft.genre=article&rft.atitle=MicroRNA+expression+profiles+classify+human+cancers&rft.jtitle=Nature&rft.aulast=Lu+J%2C+Getz+G%2C+Miska+EA%2C+Alvarez-Saavedra+E%2C+Lamb+J%2C+Peck+D%2C+Sweet-Cordero+A%2C+Ebert+BL%2C+Mak+RH%2C+Ferrando+AA%2C+Downing+JR%2C+Jacks+T%2C+Horvitz+HR%2C+Golub+TR&rft.au=Lu+J%2C+Getz+G%2C+Miska+EA%2C+Alvarez-Saavedra+E%2C+Lamb+J%2C+Peck+D%2C+Sweet-Cordero+A%2C+Ebert+BL%2C+Mak+RH%2C+Ferrando+AA%2C+Downing+JR%2C+Jacks+T%2C+Horvitz+HR%2C+Golub+TR&rft.date=2005&rft.volume=435&rft.issue=7043&rft.pages=834%E2%80%938&rft_id=info:doi/10.1038%2Fnature03702&rft_id=info:pmid/15944708&rfr_id=info:sid/en.wikipedia.org:Non-coding_RNA"> </li>
<li id="cite_note-pmid11890990-38"><a href="#cite_ref-pmid11890990_38-0">^</a> Pibouin L, Villaudy J, Ferbus D, Muleris M, Prospéri MT, Remvikos Y, Goubin G (2002). "Cloning of the mRNA of overexpression in colon carcinoma-1: a sequence overexpressed in a subset of colon carcinomas". Cancer Genet Cytogenet 133 (1): 55–60. <a title="Digital object identifier" href="/wiki/Digital_object_identifier">doi</a>:<a class="external text" href="http://dx.doi.org/10.1016%2FS0165-4608%2801%2900634-3" rel="nofollow">10.1016/S0165-4608(01)00634-3</a>. <a class="mw-redirect" title="PubMed Identifier" href="/wiki/PubMed_Identifier">PMID</a> <a class="external text" href="http://www.ncbi.nlm.nih.gov/pubmed/11890990" rel="nofollow">11890990</a>.<span class="Z3988" title="ctx_ver=Z39.88-2004&rft_val_fmt=info%3Aofi%2Ffmt%3Akev%3Amtx%3Ajournal&rft.genre=article&rft.atitle=Cloning+of+the+mRNA+of+overexpression+in+colon+carcinoma-1%3A+a+sequence+overexpressed+in+a+subset+of+colon+carcinomas&rft.jtitle=Cancer+Genet+Cytogenet&rft.aulast=Pibouin+L%2C+Villaudy+J%2C+Ferbus+D%2C+Muleris+M%2C+Prosp%C3%A9ri+MT%2C+Remvikos+Y%2C+Goubin+G&rft.au=Pibouin+L%2C+Villaudy+J%2C+Ferbus+D%2C+Muleris+M%2C+Prosp%C3%A9ri+MT%2C+Remvikos+Y%2C+Goubin+G&rft.date=2002&rft.volume=133&rft.issue=1&rft.pages=55%E2%80%9360&rft_id=info:doi/10.1016%2FS0165-4608%2801%2900634-3&rft_id=info:pmid/11890990&rfr_id=info:sid/en.wikipedia.org:Non-coding_RNA"> </li>
<li id="cite_note-pmid16569192-39"><a href="#cite_ref-pmid16569192_39-0">^</a> Fu X, Ravindranath L, Tran N, Petrovics G, Srivastava S (2006). "Regulation of apoptosis by a prostate-specific and prostate cancer-associated noncoding gene, PCGEM1". DNA Cell Biol 25 (3): 135–41. <a title="Digital object identifier" href="/wiki/Digital_object_identifier">doi</a>:<a class="external text" href="http://dx.doi.org/10.1089%2Fdna.2006.25.135" rel="nofollow">10.1089/dna.2006.25.135</a>. <a class="mw-redirect" title="PubMed Identifier" href="/wiki/PubMed_Identifier">PMID</a> <a class="external text" href="http://www.ncbi.nlm.nih.gov/pubmed/16569192" rel="nofollow">16569192</a>.<span class="Z3988" title="ctx_ver=Z39.88-2004&rft_val_fmt=info%3Aofi%2Ffmt%3Akev%3Amtx%3Ajournal&rft.genre=article&rft.atitle=Regulation+of+apoptosis+by+a+prostate-specific+and+prostate+cancer-associated+noncoding+gene%2C+PCGEM1&rft.jtitle=DNA+Cell+Biol&rft.aulast=Fu+X%2C+Ravindranath+L%2C+Tran+N%2C+Petrovics+G%2C+Srivastava+S&rft.au=Fu+X%2C+Ravindranath+L%2C+Tran+N%2C+Petrovics+G%2C+Srivastava+S&rft.date=2006&rft.volume=25&rft.issue=3&rft.pages=135%E2%80%9341&rft_id=info:doi/10.1089%2Fdna.2006.25.135&rft_id=info:pmid/16569192&rfr_id=info:sid/en.wikipedia.org:Non-coding_RNA"> </li>
<li id="cite_note-pmid18836484-40"><a href="#cite_ref-pmid18836484_40-0">^</a> Mourtada-Maarabouni M, Pickard MR, Hedge VL, Farzaneh F, Williams GT (2009). "GAS5, a non-protein-coding RNA, controls apoptosis and is downregulated in breast cancer.". Oncogene 28 (2): 195–208. <a title="Digital object identifier" href="/wiki/Digital_object_identifier">doi</a>:<a class="external text" href="http://dx.doi.org/10.1038%2Fonc.2008.373" rel="nofollow">10.1038/onc.2008.373</a>. <a class="mw-redirect" title="PubMed Identifier" href="/wiki/PubMed_Identifier">PMID</a> <a class="external text" href="http://www.ncbi.nlm.nih.gov/pubmed/18836484" rel="nofollow">18836484</a>.<span class="Z3988" title="ctx_ver=Z39.88-2004&rft_val_fmt=info%3Aofi%2Ffmt%3Akev%3Amtx%3Ajournal&rft.genre=article&rft.atitle=GAS5%2C+a+non-protein-coding+RNA%2C+controls+apoptosis+and+is+downregulated+in+breast+cancer.&rft.jtitle=Oncogene&rft.aulast=Mourtada-Maarabouni+M%2C+Pickard+MR%2C+Hedge+VL%2C+Farzaneh+F%2C+Williams+GT&rft.au=Mourtada-Maarabouni+M%2C+Pickard+MR%2C+Hedge+VL%2C+Farzaneh+F%2C+Williams+GT&rft.date=2009&rft.volume=28&rft.issue=2&rft.pages=195%E2%80%93208&rft_id=info:doi/10.1038%2Fonc.2008.373&rft_id=info:pmid/18836484&rfr_id=info:sid/en.wikipedia.org:Non-coding_RNA"> </li>
<li id="cite_note-pmid19683667-41"><a href="#cite_ref-pmid19683667_41-0">^</a> Dong XY, Guo P, Boyd J, Sun X, Li Q, Zhou W, Dong JT (2009). <a class="external text" href="http://www.pubmedcentral.nih.gov/articlerender.fcgi?tool=pmcentrez&artid=2854654" rel="nofollow">"Implication of snoRNA U50 in human breast cancer."</a>. J Genet Genomics 36 (8): 447–54. <a title="Digital object identifier" href="/wiki/Digital_object_identifier">doi</a>:<a class="external text" href="http://dx.doi.org/10.1016%2FS1673-8527%2808%2960134-4" rel="nofollow">10.1016/S1673-8527(08)60134-4</a>. <a title="PubMed Central" href="/wiki/PubMed_Central">PMC</a> <a class="external text" href="http://www.pubmedcentral.gov/articlerender.fcgi?tool=pmcentrez&artid=2854654" rel="nofollow">2854654</a>. <a class="mw-redirect" title="PubMed Identifier" href="/wiki/PubMed_Identifier">PMID</a> <a class="external text" href="http://www.ncbi.nlm.nih.gov/pubmed/19683667" rel="nofollow">19683667</a>. <a class="external free" href="http://www.pubmedcentral.nih.gov/articlerender.fcgi?tool=pmcentrez&artid=2854654" rel="nofollow">http://www.pubmedcentral.nih.gov/articlerender.fcgi?tool=pmcentrez&artid=2854654</a>.<span class="Z3988" title="ctx_ver=Z39.88-2004&rft_val_fmt=info%3Aofi%2Ffmt%3Akev%3Amtx%3Ajournal&rft.genre=article&rft.atitle=Implication+of+snoRNA+U50+in+human+breast+cancer.&rft.jtitle=J+Genet+Genomics&rft.aulast=Dong+XY%2C+Guo+P%2C+Boyd+J%2C+Sun+X%2C+Li+Q%2C+Zhou+W%2C+Dong+JT&rft.au=Dong+XY%2C+Guo+P%2C+Boyd+J%2C+Sun+X%2C+Li+Q%2C+Zhou+W%2C+Dong+JT&rft.date=2009&rft.volume=36&rft.issue=8&rft.pages=447%E2%80%9354&rft_id=info:doi/10.1016%2FS1673-8527%2808%2960134-4&rft_id=info:pmc/2854654&rft_id=info:pmid/19683667&rft_id=http%3A%2F%2Fwww.pubmedcentral.nih.gov%2Farticlerender.fcgi%3Ftool%3Dpmcentrez%26artid%3D2854654&rfr_id=info:sid/en.wikipedia.org:Non-coding_RNA"> </li>
<li id="cite_note-pmid18283318-42"><a href="#cite_ref-pmid18283318_42-0">^</a> Christov CP, Trivier E, Krude T (2008). <a class="external text" href="http://www.pubmedcentral.nih.gov/articlerender.fcgi?tool=pmcentrez&artid=2266855" rel="nofollow">"Noncoding human Y RNAs are overexpressed in tumours and required for cell proliferation"</a>. Br J Cancer 98 (5): 981–8. <a title="Digital object identifier" href="/wiki/Digital_object_identifier">doi</a>:<a class="external text" href="http://dx.doi.org/10.1038%2Fsj.bjc.6604254" rel="nofollow">10.1038/sj.bjc.6604254</a>. <a title="PubMed Central" href="/wiki/PubMed_Central">PMC</a> <a class="external text" href="http://www.pubmedcentral.gov/articlerender.fcgi?tool=pmcentrez&artid=2266855" rel="nofollow">2266855</a>. <a class="mw-redirect" title="PubMed Identifier" href="/wiki/PubMed_Identifier">PMID</a> <a class="external text" href="http://www.ncbi.nlm.nih.gov/pubmed/18283318" rel="nofollow">18283318</a>. <a class="external free" href="http://www.pubmedcentral.nih.gov/articlerender.fcgi?tool=pmcentrez&artid=2266855" rel="nofollow">http://www.pubmedcentral.nih.gov/articlerender.fcgi?tool=pmcentrez&artid=2266855</a>.<span class="Z3988" title="ctx_ver=Z39.88-2004&rft_val_fmt=info%3Aofi%2Ffmt%3Akev%3Amtx%3Ajournal&rft.genre=article&rft.atitle=Noncoding+human+Y+RNAs+are+overexpressed+in+tumours+and+required+for+cell+proliferation&rft.jtitle=Br+J+Cancer&rft.aulast=Christov+CP%2C+Trivier+E%2C+Krude+T&rft.au=Christov+CP%2C+Trivier+E%2C+Krude+T&rft.date=2008&rft.volume=98&rft.issue=5&rft.pages=981%E2%80%938&rft_id=info:doi/10.1038%2Fsj.bjc.6604254&rft_id=info:pmc/2266855&rft_id=info:pmid/18283318&rft_id=http%3A%2F%2Fwww.pubmedcentral.nih.gov%2Farticlerender.fcgi%3Ftool%3Dpmcentrez%26artid%3D2266855&rfr_id=info:sid/en.wikipedia.org:Non-coding_RNA"> </li>
<li id="cite_note-pmid16308420-43"><a href="#cite_ref-pmid16308420_43-0">^</a> Farh KK, Grimson A, Jan C, Lewis BP, Johnston WK, Lim LP, Burge CB, Bartel DP (2005). "The widespread impact of mammalian MicroRNAs on mRNA repression and evolution". Science 310 (5755): 1817–21. <a title="Digital object identifier" href="/wiki/Digital_object_identifier">doi</a>:<a class="external text" href="http://dx.doi.org/10.1126%2Fscience.1121158" rel="nofollow">10.1126/science.1121158</a>. <a class="mw-redirect" title="PubMed Identifier" href="/wiki/PubMed_Identifier">PMID</a> <a class="external text" href="http://www.ncbi.nlm.nih.gov/pubmed/16308420" rel="nofollow">16308420</a>.<span class="Z3988" title="ctx_ver=Z39.88-2004&rft_val_fmt=info%3Aofi%2Ffmt%3Akev%3Amtx%3Ajournal&rft.genre=article&rft.atitle=The+widespread+impact+of+mammalian+MicroRNAs+on+mRNA+repression+and+evolution&rft.jtitle=Science&rft.aulast=Farh+KK%2C+Grimson+A%2C+Jan+C%2C+Lewis+BP%2C+Johnston+WK%2C+Lim+LP%2C+Burge+CB%2C+Bartel+DP&rft.au=Farh+KK%2C+Grimson+A%2C+Jan+C%2C+Lewis+BP%2C+Johnston+WK%2C+Lim+LP%2C+Burge+CB%2C+Bartel+DP&rft.date=2005&rft.volume=310&rft.issue=5755&rft.pages=1817%E2%80%9321&rft_id=info:doi/10.1126%2Fscience.1121158&rft_id=info:pmid/16308420&rfr_id=info:sid/en.wikipedia.org:Non-coding_RNA"> </li>
<li id="cite_note-pmid15685193-44"><a href="#cite_ref-pmid15685193_44-0">^</a> Lim LP, Lau NC, Garrett-Engele P, Grimson A, Schelter JM, Castle J, Bartel DP, Linsley PS, Johnson JM (2005). "Microarray analysis shows that some microRNAs downregulate large numbers of target mRNAs". Nature 433 (7027): 769–73. <a title="Digital object identifier" href="/wiki/Digital_object_identifier">doi</a>:<a class="external text" href="http://dx.doi.org/10.1038%2Fnature03315" rel="nofollow">10.1038/nature03315</a>. <a class="mw-redirect" title="PubMed Identifier" href="/wiki/PubMed_Identifier">PMID</a> <a class="external text" href="http://www.ncbi.nlm.nih.gov/pubmed/15685193" rel="nofollow">15685193</a>.<span class="Z3988" title="ctx_ver=Z39.88-2004&rft_val_fmt=info%3Aofi%2Ffmt%3Akev%3Amtx%3Ajournal&rft.genre=article&rft.atitle=Microarray+analysis+shows+that+some+microRNAs+downregulate+large+numbers+of+target+mRNAs&rft.jtitle=Nature&rft.aulast=Lim+LP%2C+Lau+NC%2C+Garrett-Engele+P%2C+Grimson+A%2C+Schelter+JM%2C+Castle+J%2C+Bartel+DP%2C+Linsley+PS%2C+Johnson+JM&rft.au=Lim+LP%2C+Lau+NC%2C+Garrett-Engele+P%2C+Grimson+A%2C+Schelter+JM%2C+Castle+J%2C+Bartel+DP%2C+Linsley+PS%2C+Johnson+JM&rft.date=2005&rft.volume=433&rft.issue=7027&rft.pages=769%E2%80%9373&rft_id=info:doi/10.1038%2Fnature03315&rft_id=info:pmid/15685193&rfr_id=info:sid/en.wikipedia.org:Non-coding_RNA"> </li>
<li id="cite_note-pmid16943439-45"><a href="#cite_ref-pmid16943439_45-0">^</a> Christov CP, Gardiner TJ, Szüts D, Krude T (2006). <a class="external text" href="http://www.pubmedcentral.nih.gov/articlerender.fcgi?tool=pmcentrez&artid=1592862" rel="nofollow">"Functional requirement of noncoding Y RNAs for human chromosomal DNA replication"</a>. Mol Cell Biol 26 (18): 6993–7004. <a title="Digital object identifier" href="/wiki/Digital_object_identifier">doi</a>:<a class="external text" href="http://dx.doi.org/10.1128%2FMCB.01060-06" rel="nofollow">10.1128/MCB.01060-06</a>. <a title="PubMed Central" href="/wiki/PubMed_Central">PMC</a> <a class="external text" href="http://www.pubmedcentral.gov/articlerender.fcgi?tool=pmcentrez&artid=1592862" rel="nofollow">1592862</a>. <a class="mw-redirect" title="PubMed Identifier" href="/wiki/PubMed_Identifier">PMID</a> <a class="external text" href="http://www.ncbi.nlm.nih.gov/pubmed/16943439" rel="nofollow">16943439</a>. <a class="external free" href="http://www.pubmedcentral.nih.gov/articlerender.fcgi?tool=pmcentrez&artid=1592862" rel="nofollow">http://www.pubmedcentral.nih.gov/articlerender.fcgi?tool=pmcentrez&artid=1592862</a>.<span class="Z3988" title="ctx_ver=Z39.88-2004&rft_val_fmt=info%3Aofi%2Ffmt%3Akev%3Amtx%3Ajournal&rft.genre=article&rft.atitle=Functional+requirement+of+noncoding+Y+RNAs+for+human+chromosomal+DNA+replication&rft.jtitle=Mol+Cell+Biol&rft.aulast=Christov+CP%2C+Gardiner+TJ%2C+Sz%C3%BCts+D%2C+Krude+T&rft.au=Christov+CP%2C+Gardiner+TJ%2C+Sz%C3%BCts+D%2C+Krude+T&rft.date=2006&rft.volume=26&rft.issue=18&rft.pages=6993%E2%80%937004&rft_id=info:doi/10.1128%2FMCB.01060-06&rft_id=info:pmc/1592862&rft_id=info:pmid/16943439&rft_id=http%3A%2F%2Fwww.pubmedcentral.nih.gov%2Farticlerender.fcgi%3Ftool%3Dpmcentrez%26artid%3D1592862&rfr_id=info:sid/en.wikipedia.org:Non-coding_RNA"> </li>
<li id="cite_note-pmid16251535-46"><a href="#cite_ref-pmid16251535_46-0">^</a> Calin GA, Ferracin M, Cimmino A, et al (October 2005). <a class="external text" href="http://content.nejm.org/cgi/content/full/353/17/1793" rel="nofollow">"A MicroRNA signature associated with prognosis and progression in chronic lymphocytic leukemia"</a>. N. Engl. J. Med. 353 (17): 1793–801. <a title="Digital object identifier" href="/wiki/Digital_object_identifier">doi</a>:<a class="external text" href="http://dx.doi.org/10.1056%2FNEJMoa050995" rel="nofollow">10.1056/NEJMoa050995</a>. <a class="mw-redirect" title="PubMed Identifier" href="/wiki/PubMed_Identifier">PMID</a> <a class="external text" href="http://www.ncbi.nlm.nih.gov/pubmed/16251535" rel="nofollow">16251535</a>. <a class="external free" href="http://content.nejm.org/cgi/content/full/353/17/1793" rel="nofollow">http://content.nejm.org/cgi/content/full/353/17/1793</a>.<span class="Z3988" title="ctx_ver=Z39.88-2004&rft_val_fmt=info%3Aofi%2Ffmt%3Akev%3Amtx%3Ajournal&rft.genre=article&rft.atitle=A+MicroRNA+signature+associated+with+prognosis+and+progression+in+chronic+lymphocytic+leukemia&rft.jtitle=N.+Engl.+J.+Med.&rft.aulast=Calin+GA%2C+Ferracin+M%2C+Cimmino+A%2C+%27%27et+al%27%27&rft.au=Calin+GA%2C+Ferracin+M%2C+Cimmino+A%2C+%27%27et+al%27%27&rft.date=October+2005&rft.volume=353&rft.issue=17&rft.pages=1793%E2%80%93801&rft_id=info:doi/10.1056%2FNEJMoa050995&rft_id=info:pmid/16251535&rft_id=http%3A%2F%2Fcontent.nejm.org%2Fcgi%2Fcontent%2Ffull%2F353%2F17%2F1793&rfr_id=info:sid/en.wikipedia.org:Non-coding_RNA"> </li>
<li id="cite_note-47"><a href="#cite_ref-47">^</a> Calin, GA; Dumitru CD, Shimizu M, Bichi R, Zupo S, Noch E, Aldler H, Rattan S, Keating M, Rai K, Rassenti L, Kipps T, Negrini M, Bullrich F, Croce CM (2002). <a class="external text" href="http://www.pubmedcentral.nih.gov/articlerender.fcgi?tool=pmcentrez&artid=137750" rel="nofollow">"Frequent deletions and down-regulation of micro-RNA genes miR15 and miR16 at 13q14 in chronic lymphocytic leukemia"</a>. Proc Natl Acad Sci USA 99 (24): 15524–15529. <a title="Digital object identifier" href="/wiki/Digital_object_identifier">doi</a>:<a class="external text" href="http://dx.doi.org/10.1073%2Fpnas.242606799" rel="nofollow">10.1073/pnas.242606799</a>. <a title="PubMed Central" href="/wiki/PubMed_Central">PMC</a> <a class="external text" href="http://www.pubmedcentral.gov/articlerender.fcgi?tool=pmcentrez&artid=137750" rel="nofollow">137750</a>. <a class="mw-redirect" title="PubMed Identifier" href="/wiki/PubMed_Identifier">PMID</a> <a class="external text" href="http://www.ncbi.nlm.nih.gov/pubmed/12434020" rel="nofollow">12434020</a>. <a class="external free" href="http://www.pubmedcentral.nih.gov/articlerender.fcgi?tool=pmcentrez&artid=137750" rel="nofollow">http://www.pubmedcentral.nih.gov/articlerender.fcgi?tool=pmcentrez&artid=137750</a>.<span class="Z3988" title="ctx_ver=Z39.88-2004&rft_val_fmt=info%3Aofi%2Ffmt%3Akev%3Amtx%3Ajournal&rft.genre=article&rft.atitle=Frequent+deletions+and+down-regulation+of+micro-RNA+genes+miR15+and+miR16+at+13q14+in+chronic+lymphocytic+leukemia&rft.jtitle=Proc+Natl+Acad+Sci+USA&rft.aulast=Calin&rft.aufirst=GA&rft.au=Calin%2C%26%2332%3BGA&rft.date=2002&rft.volume=99&rft.issue=24&rft.pages=15524%26ndash%3B15529&rft_id=info:doi/10.1073%2Fpnas.242606799&rft_id=info:pmc/137750&rft_id=info:pmid/12434020&rft_id=http%3A%2F%2Fwww.pubmedcentral.nih.gov%2Farticlerender.fcgi%3Ftool%3Dpmcentrez%26artid%3D137750&rfr_id=info:sid/en.wikipedia.org:Non-coding_RNA"> </li>
<li id="cite_note-pmid18521189-48"><a href="#cite_ref-pmid18521189_48-0">^</a> Hu Z, Chen J, Tian T, Zhou X, Gu H, Xu L, Zeng Y, Miao R, Jin G, Ma H, Chen Y, Shen H (2008). <a class="external text" href="http://www.pubmedcentral.nih.gov/articlerender.fcgi?tool=pmcentrez&artid=2402113" rel="nofollow">"Genetic variants of miRNA sequences and non-small cell lung cancer survival"</a>. J Clin Invest 118 (7): 2600–8. <a title="Digital object identifier" href="/wiki/Digital_object_identifier">doi</a>:<a class="external text" href="http://dx.doi.org/10.1172%2FJCI34934" rel="nofollow">10.1172/JCI34934</a>. <a title="PubMed Central" href="/wiki/PubMed_Central">PMC</a> <a class="external text" href="http://www.pubmedcentral.gov/articlerender.fcgi?tool=pmcentrez&artid=2402113" rel="nofollow">2402113</a>. <a class="mw-redirect" title="PubMed Identifier" href="/wiki/PubMed_Identifier">PMID</a> <a class="external text" href="http://www.ncbi.nlm.nih.gov/pubmed/18521189" rel="nofollow">18521189</a>. <a class="external free" href="http://www.pubmedcentral.nih.gov/articlerender.fcgi?tool=pmcentrez&artid=2402113" rel="nofollow">http://www.pubmedcentral.nih.gov/articlerender.fcgi?tool=pmcentrez&artid=2402113</a>.<span class="Z3988" title="ctx_ver=Z39.88-2004&rft_val_fmt=info%3Aofi%2Ffmt%3Akev%3Amtx%3Ajournal&rft.genre=article&rft.atitle=Genetic+variants+of+miRNA+sequences+and+non-small+cell+lung+cancer+survival&rft.jtitle=J+Clin+Invest&rft.aulast=Hu+Z%2C+Chen+J%2C+Tian+T%2C+Zhou+X%2C+Gu+H%2C+Xu+L%2C+Zeng+Y%2C+Miao+R%2C+Jin+G%2C+Ma+H%2C+Chen+Y%2C+Shen+H&rft.au=Hu+Z%2C+Chen+J%2C+Tian+T%2C+Zhou+X%2C+Gu+H%2C+Xu+L%2C+Zeng+Y%2C+Miao+R%2C+Jin+G%2C+Ma+H%2C+Chen+Y%2C+Shen+H&rft.date=2008&rft.volume=118&rft.issue=7&rft.pages=2600%E2%80%938&rft_id=info:doi/10.1172%2FJCI34934&rft_id=info:pmc/2402113&rft_id=info:pmid/18521189&rft_id=http%3A%2F%2Fwww.pubmedcentral.nih.gov%2Farticlerender.fcgi%3Ftool%3Dpmcentrez%26artid%3D2402113&rfr_id=info:sid/en.wikipedia.org:Non-coding_RNA"> </li>
<li id="cite_note-pmid19048628-49"><a href="#cite_ref-pmid19048628_49-0">^</a> Shen J, Ambrosone CB, Zhao H (2009). "Novel genetic variants in microRNA genes and familial breast cancer". Int J Cancer 124 (5): 1178–82. <a title="Digital object identifier" href="/wiki/Digital_object_identifier">doi</a>:<a class="external text" href="http://dx.doi.org/10.1002%2Fijc.24008" rel="nofollow">10.1002/ijc.24008</a>. <a class="mw-redirect" title="PubMed Identifier" href="/wiki/PubMed_Identifier">PMID</a> <a class="external text" href="http://www.ncbi.nlm.nih.gov/pubmed/19048628" rel="nofollow">19048628</a>.<span class="Z3988" title="ctx_ver=Z39.88-2004&rft_val_fmt=info%3Aofi%2Ffmt%3Akev%3Amtx%3Ajournal&rft.genre=article&rft.atitle=Novel+genetic+variants+in+microRNA+genes+and+familial+breast+cancer&rft.jtitle=Int+J+Cancer&rft.aulast=Shen+J%2C+Ambrosone+CB%2C+Zhao+H&rft.au=Shen+J%2C+Ambrosone+CB%2C+Zhao+H&rft.date=2009&rft.volume=124&rft.issue=5&rft.pages=1178%E2%80%9382&rft_id=info:doi/10.1002%2Fijc.24008&rft_id=info:pmid/19048628&rfr_id=info:sid/en.wikipedia.org:Non-coding_RNA"> </li>
<li id="cite_note-pmid18500341-50"><a href="#cite_ref-pmid18500341_50-0">^</a> Sahoo T, del Gaudio D, German JR, Shinawi M, Peters SU, Person RE, Garnica A, Cheung SW, Beaudet AL (2008). <a class="external text" href="http://www.pubmedcentral.nih.gov/articlerender.fcgi?tool=pmcentrez&artid=2705197" rel="nofollow">"Prader–Willi phenotype caused by paternal deficiency for the HBII-85 C/D box small nucleolar RNA cluster."</a>. Nat Genet 40 (6): 719–21. <a title="Digital object identifier" href="/wiki/Digital_object_identifier">doi</a>:<a class="external text" href="http://dx.doi.org/10.1038%2Fng.158" rel="nofollow">10.1038/ng.158</a>. <a title="PubMed Central" href="/wiki/PubMed_Central">PMC</a> <a class="external text" href="http://www.pubmedcentral.gov/articlerender.fcgi?tool=pmcentrez&artid=2705197" rel="nofollow">2705197</a>. <a class="mw-redirect" title="PubMed Identifier" href="/wiki/PubMed_Identifier">PMID</a> <a class="external text" href="http://www.ncbi.nlm.nih.gov/pubmed/18500341" rel="nofollow">18500341</a>. <a class="external free" href="http://www.pubmedcentral.nih.gov/articlerender.fcgi?tool=pmcentrez&artid=2705197" rel="nofollow">http://www.pubmedcentral.nih.gov/articlerender.fcgi?tool=pmcentrez&artid=2705197</a>.<span class="Z3988" title="ctx_ver=Z39.88-2004&rft_val_fmt=info%3Aofi%2Ffmt%3Akev%3Amtx%3Ajournal&rft.genre=article&rft.atitle=Prader%26ndash%3BWilli+phenotype+caused+by+paternal+deficiency+for+the+HBII-85+C%2FD+box+small+nucleolar+RNA+cluster.&rft.jtitle=Nat+Genet&rft.aulast=Sahoo+T%2C+del+Gaudio+D%2C+German+JR%2C+Shinawi+M%2C+Peters+SU%2C+Person+RE%2C+Garnica+A%2C+Cheung+SW%2C+Beaudet+AL&rft.au=Sahoo+T%2C+del+Gaudio+D%2C+German+JR%2C+Shinawi+M%2C+Peters+SU%2C+Person+RE%2C+Garnica+A%2C+Cheung+SW%2C+Beaudet+AL&rft.date=2008&rft.volume=40&rft.issue=6&rft.pages=719%E2%80%9321&rft_id=info:doi/10.1038%2Fng.158&rft_id=info:pmc/2705197&rft_id=info:pmid/18500341&rft_id=http%3A%2F%2Fwww.pubmedcentral.nih.gov%2Farticlerender.fcgi%3Ftool%3Dpmcentrez%26artid%3D2705197&rfr_id=info:sid/en.wikipedia.org:Non-coding_RNA"> </li>
<li id="cite_note-pmid18320030-51"><a href="#cite_ref-pmid18320030_51-0">^</a> Ding F, Li HH, Zhang S, Solomon NM, Camper SA, Cohen P, Francke U (2008). <a class="external text" href="http://www.pubmedcentral.nih.gov/articlerender.fcgi?tool=pmcentrez&artid=2248623" rel="nofollow">"SnoRNA Snord116 (Pwcr1/MBII-85) deletion causes growth deficiency and hyperphagia in mice."</a>. PLoS ONE 3 (3): e1709. <a title="Digital object identifier" href="/wiki/Digital_object_identifier">doi</a>:<a class="external text" href="http://dx.doi.org/10.1371%2Fjournal.pone.0001709" rel="nofollow">10.1371/journal.pone.0001709</a>. <a title="PubMed Central" href="/wiki/PubMed_Central">PMC</a> <a class="external text" href="http://www.pubmedcentral.gov/articlerender.fcgi?tool=pmcentrez&artid=2248623" rel="nofollow">2248623</a>. <a class="mw-redirect" title="PubMed Identifier" href="/wiki/PubMed_Identifier">PMID</a> <a class="external text" href="http://www.ncbi.nlm.nih.gov/pubmed/18320030" rel="nofollow">18320030</a>. <a class="external free" href="http://www.pubmedcentral.nih.gov/articlerender.fcgi?tool=pmcentrez&artid=2248623" rel="nofollow">http://www.pubmedcentral.nih.gov/articlerender.fcgi?tool=pmcentrez&artid=2248623</a>.<span class="Z3988" title="ctx_ver=Z39.88-2004&rft_val_fmt=info%3Aofi%2Ffmt%3Akev%3Amtx%3Ajournal&rft.genre=article&rft.atitle=SnoRNA+Snord116+%28Pwcr1%2FMBII-85%29+deletion+causes+growth+deficiency+and+hyperphagia+in+mice.&rft.jtitle=PLoS+ONE&rft.aulast=Ding+F%2C+Li+HH%2C+Zhang+S%2C+Solomon+NM%2C+Camper+SA%2C+Cohen+P%2C+Francke+U&rft.au=Ding+F%2C+Li+HH%2C+Zhang+S%2C+Solomon+NM%2C+Camper+SA%2C+Cohen+P%2C+Francke+U&rft.date=2008&rft.volume=3&rft.issue=3&rft.pages=e1709&rft_id=info:doi/10.1371%2Fjournal.pone.0001709&rft_id=info:pmc/2248623&rft_id=info:pmid/18320030&rft_id=http%3A%2F%2Fwww.pubmedcentral.nih.gov%2Farticlerender.fcgi%3Ftool%3Dpmcentrez%26artid%3D2248623&rfr_id=info:sid/en.wikipedia.org:Non-coding_RNA"> </li>
<li id="cite_note-pmid16075369-52"><a href="#cite_ref-pmid16075369_52-0">^</a> Ding F, Prints Y, Dhar MS, Johnson DK, Garnacho-Montero C, Nicholls RD, Francke U (2005). "Lack of Pwcr1/MBII-85 snoRNA is critical for neonatal lethality in Prader–Willi syndrome mouse models.". Mamm Genome 16 (6): 424–31. <a title="Digital object identifier" href="/wiki/Digital_object_identifier">doi</a>:<a class="external text" href="http://dx.doi.org/10.1007%2Fs00335-005-2460-2" rel="nofollow">10.1007/s00335-005-2460-2</a>. <a class="mw-redirect" title="PubMed Identifier" href="/wiki/PubMed_Identifier">PMID</a> <a class="external text" href="http://www.ncbi.nlm.nih.gov/pubmed/16075369" rel="nofollow">16075369</a>.<span class="Z3988" title="ctx_ver=Z39.88-2004&rft_val_fmt=info%3Aofi%2Ffmt%3Akev%3Amtx%3Ajournal&rft.genre=article&rft.atitle=Lack+of+Pwcr1%2FMBII-85+snoRNA+is+critical+for+neonatal+lethality+in+Prader%26ndash%3BWilli+syndrome+mouse+models.&rft.jtitle=Mamm+Genome&rft.aulast=Ding+F%2C+Prints+Y%2C+Dhar+MS%2C+Johnson+DK%2C+Garnacho-Montero+C%2C+Nicholls+RD%2C+Francke+U&rft.au=Ding+F%2C+Prints+Y%2C+Dhar+MS%2C+Johnson+DK%2C+Garnacho-Montero+C%2C+Nicholls+RD%2C+Francke+U&rft.date=2005&rft.volume=16&rft.issue=6&rft.pages=424%E2%80%9331&rft_id=info:doi/10.1007%2Fs00335-005-2460-2&rft_id=info:pmid/16075369&rfr_id=info:sid/en.wikipedia.org:Non-coding_RNA"> </li>
<li id="cite_note-pmid18160232-53"><a href="#cite_ref-pmid18160232_53-0">^</a> Bazeley PS, Shepelev V, Talebizadeh Z, Butler MG, Fedorova L, Filatov V, Fedorov A (2008). "snoTARGET shows that human orphan snoRNA targets locate close to alternative splice junctions.". Gene 408 (1-2): 172–9. <a title="Digital object identifier" href="/wiki/Digital_object_identifier">doi</a>:<a class="external text" href="http://dx.doi.org/10.1016%2Fj.gene.2007.10.037" rel="nofollow">10.1016/j.gene.2007.10.037</a>. <a class="mw-redirect" title="PubMed Identifier" href="/wiki/PubMed_Identifier">PMID</a> <a class="external text" href="http://www.ncbi.nlm.nih.gov/pubmed/18160232" rel="nofollow">18160232</a>.<span class="Z3988" title="ctx_ver=Z39.88-2004&rft_val_fmt=info%3Aofi%2Ffmt%3Akev%3Amtx%3Ajournal&rft.genre=article&rft.atitle=snoTARGET+shows+that+human+orphan+snoRNA+targets+locate+close+to+alternative+splice+junctions.&rft.jtitle=Gene&rft.aulast=Bazeley+PS%2C+Shepelev+V%2C+Talebizadeh+Z%2C+Butler+MG%2C+Fedorova+L%2C+Filatov+V%2C+Fedorov+A&rft.au=Bazeley+PS%2C+Shepelev+V%2C+Talebizadeh+Z%2C+Butler+MG%2C+Fedorova+L%2C+Filatov+V%2C+Fedorov+A&rft.date=2008&rft.volume=408&rft.issue=1-2&rft.pages=172%E2%80%939&rft_id=info:doi/10.1016%2Fj.gene.2007.10.037&rft_id=info:pmid/18160232&rfr_id=info:sid/en.wikipedia.org:Non-coding_RNA"> </li>
<li id="cite_note-pmid15318025-54"><a href="#cite_ref-pmid15318025_54-0">^</a> Bolton PF, Veltman MW, Weisblatt E, et al. (September 2004). <a class="external text" href="http://meta.wkhealth.com/pt/pt-core/template-journal/lwwgateway/media/landingpage.htm?issn=0955-8829&volume=14&issue=3&spage=131" rel="nofollow">"Chromosome 15q11-13 abnormalities and other medical conditions in individuals with autism spectrum disorders"</a>. Psychiatr. Genet. 14 (3): 131–7. <a title="Digital object identifier" href="/wiki/Digital_object_identifier">doi</a>:<a class="external text" href="http://dx.doi.org/10.1097%2F00041444-200409000-00002" rel="nofollow">10.1097/00041444-200409000-00002</a>. <a class="mw-redirect" title="PubMed Identifier" href="/wiki/PubMed_Identifier">PMID</a> <a class="external text" href="http://www.ncbi.nlm.nih.gov/pubmed/15318025" rel="nofollow">15318025</a>. <a class="external free" href="http://meta.wkhealth.com/pt/pt-core/template-journal/lwwgateway/media/landingpage.htm?issn=0955-8829&volume=14&issue=3&spage=131" rel="nofollow">http://meta.wkhealth.com/pt/pt-core/template-journal/lwwgateway/media/landingpage.htm?issn=0955-8829&volume=14&issue=3&spage=131</a>.<span class="Z3988" title="ctx_ver=Z39.88-2004&rft_val_fmt=info%3Aofi%2Ffmt%3Akev%3Amtx%3Ajournal&rft.genre=article&rft.atitle=Chromosome+15q11-13+abnormalities+and+other+medical+conditions+in+individuals+with+autism+spectrum+disorders&rft.jtitle=Psychiatr.+Genet.&rft.aulast=Bolton+PF%2C+Veltman+MW%2C+Weisblatt+E%2C+%27%27et+al.%27%27&rft.au=Bolton+PF%2C+Veltman+MW%2C+Weisblatt+E%2C+%27%27et+al.%27%27&rft.date=September+2004&rft.volume=14&rft.issue=3&rft.pages=131%E2%80%937&rft_id=info:doi/10.1097%2F00041444-200409000-00002&rft_id=info:pmid/15318025&rft_id=http%3A%2F%2Fmeta.wkhealth.com%2Fpt%2Fpt-core%2Ftemplate-journal%2Flwwgateway%2Fmedia%2Flandingpage.htm%3Fissn%3D0955-8829%26volume%3D14%26issue%3D3%26spage%3D131&rfr_id=info:sid/en.wikipedia.org:Non-coding_RNA"> </li>
<li id="cite_note-pmid18923514-55"><a href="#cite_ref-pmid18923514_55-0">^</a> Cook EH, Scherer SW (October 2008). "Copy-number variations associated with neuropsychiatric conditions". Nature 455 (7215): 919–23. <a title="Digital object identifier" href="/wiki/Digital_object_identifier">doi</a>:<a class="external text" href="http://dx.doi.org/10.1038%2Fnature07458" rel="nofollow">10.1038/nature07458</a>. <a class="mw-redirect" title="PubMed Identifier" href="/wiki/PubMed_Identifier">PMID</a> <a class="external text" href="http://www.ncbi.nlm.nih.gov/pubmed/18923514" rel="nofollow">18923514</a>.<span class="Z3988" title="ctx_ver=Z39.88-2004&rft_val_fmt=info%3Aofi%2Ffmt%3Akev%3Amtx%3Ajournal&rft.genre=article&rft.atitle=Copy-number+variations+associated+with+neuropsychiatric+conditions&rft.jtitle=Nature&rft.aulast=Cook+EH%2C+Scherer+SW&rft.au=Cook+EH%2C+Scherer+SW&rft.date=October+2008&rft.volume=455&rft.issue=7215&rft.pages=919%E2%80%9323&rft_id=info:doi/10.1038%2Fnature07458&rft_id=info:pmid/18923514&rfr_id=info:sid/en.wikipedia.org:Non-coding_RNA"> </li>
<li id="cite_note-pmid19563756-56"><a href="#cite_ref-pmid19563756_56-0">^</a> Nakatani J, Tamada K, Hatanaka F, et al. (June 2009). "Abnormal behavior in a chromosome-engineered mouse model for human 15q11-13 duplication seen in autism". Cell 137 (7): 1235–46. <a title="Digital object identifier" href="/wiki/Digital_object_identifier">doi</a>:<a class="external text" href="http://dx.doi.org/10.1016%2Fj.cell.2009.04.024" rel="nofollow">10.1016/j.cell.2009.04.024</a>. <a class="mw-redirect" title="PubMed Identifier" href="/wiki/PubMed_Identifier">PMID</a> <a class="external text" href="http://www.ncbi.nlm.nih.gov/pubmed/19563756" rel="nofollow">19563756</a>.<span class="Z3988" title="ctx_ver=Z39.88-2004&rft_val_fmt=info%3Aofi%2Ffmt%3Akev%3Amtx%3Ajournal&rft.genre=article&rft.atitle=Abnormal+behavior+in+a+chromosome-engineered+mouse+model+for+human+15q11-13+duplication+seen+in+autism&rft.jtitle=Cell&rft.aulast=Nakatani+J%2C+Tamada+K%2C+Hatanaka+F%2C+%27%27et+al.%27%27&rft.au=Nakatani+J%2C+Tamada+K%2C+Hatanaka+F%2C+%27%27et+al.%27%27&rft.date=June+2009&rft.volume=137&rft.issue=7&rft.pages=1235%E2%80%9346&rft_id=info:doi/10.1016%2Fj.cell.2009.04.024&rft_id=info:pmid/19563756&rfr_id=info:sid/en.wikipedia.org:Non-coding_RNA"> </li>
<li id="cite_note-pmid11207361-57"><a href="#cite_ref-pmid11207361_57-0">^</a> Ridanpää M, van Eenennaam H, Pelin K, Chadwick R, Johnson C, Yuan B, vanVenrooij W, Pruijn G, Salmela R, Rockas S, Mäkitie O, Kaitila I, de la Chapelle A (2001). "Mutations in the RNA component of RNase MRP cause a pleiotropic human disease, cartilage-hair hypoplasia.". Cell 104 (2): 195–203. <a title="Digital object identifier" href="/wiki/Digital_object_identifier">doi</a>:<a class="external text" href="http://dx.doi.org/10.1016%2FS0092-8674%2801%2900205-7" rel="nofollow">10.1016/S0092-8674(01)00205-7</a>. <a class="mw-redirect" title="PubMed Identifier" href="/wiki/PubMed_Identifier">PMID</a> <a class="external text" href="http://www.ncbi.nlm.nih.gov/pubmed/11207361" rel="nofollow">11207361</a>.<span class="Z3988" title="ctx_ver=Z39.88-2004&rft_val_fmt=info%3Aofi%2Ffmt%3Akev%3Amtx%3Ajournal&rft.genre=article&rft.atitle=Mutations+in+the+RNA+component+of+RNase+MRP+cause+a+pleiotropic+human+disease%2C+cartilage-hair+hypoplasia.&rft.jtitle=Cell&rft.aulast=Ridanp%C3%A4%C3%A4+M%2C+van+Eenennaam+H%2C+Pelin+K%2C+Chadwick+R%2C+Johnson+C%2C+Yuan+B%2C+vanVenrooij+W%2C+Pruijn+G%2C+Salmela+R%2C+Rockas+S%2C+M%C3%A4kitie+O%2C+Kaitila+I%2C+de+la+Chapelle+A&rft.au=Ridanp%C3%A4%C3%A4+M%2C+van+Eenennaam+H%2C+Pelin+K%2C+Chadwick+R%2C+Johnson+C%2C+Yuan+B%2C+vanVenrooij+W%2C+Pruijn+G%2C+Salmela+R%2C+Rockas+S%2C+M%C3%A4kitie+O%2C+Kaitila+I%2C+de+la+Chapelle+A&rft.date=2001&rft.volume=104&rft.issue=2&rft.pages=195%E2%80%93203&rft_id=info:doi/10.1016%2FS0092-8674%2801%2900205-7&rft_id=info:pmid/11207361&rfr_id=info:sid/en.wikipedia.org:Non-coding_RNA"> </li>
<li id="cite_note-pmid17189938-58"><a href="#cite_ref-pmid17189938_58-0">^</a> Martin AN, Li Y (2007). "RNase MRP RNA and human genetic diseases.". Cell Res 17 (3): 219–26. <a title="Digital object identifier" href="/wiki/Digital_object_identifier">doi</a>:<a class="external text" href="http://dx.doi.org/10.1038%2Fsj.cr.7310120" rel="nofollow">10.1038/sj.cr.7310120</a>. <a class="mw-redirect" title="PubMed Identifier" href="/wiki/PubMed_Identifier">PMID</a> <a class="external text" href="http://www.ncbi.nlm.nih.gov/pubmed/17189938" rel="nofollow">17189938</a>.<span class="Z3988" title="ctx_ver=Z39.88-2004&rft_val_fmt=info%3Aofi%2Ffmt%3Akev%3Amtx%3Ajournal&rft.genre=article&rft.atitle=RNase+MRP+RNA+and+human+genetic+diseases.&rft.jtitle=Cell+Res&rft.aulast=Martin+AN%2C+Li+Y&rft.au=Martin+AN%2C+Li+Y&rft.date=2007&rft.volume=17&rft.issue=3&rft.pages=219%E2%80%9326&rft_id=info:doi/10.1038%2Fsj.cr.7310120&rft_id=info:pmid/17189938&rfr_id=info:sid/en.wikipedia.org:Non-coding_RNA"> </li>
<li id="cite_note-pmid18804272-59"><a href="#cite_ref-pmid18804272_59-0">^</a> Kavadas FD, Giliani S, Gu Y, Mazzolari E, Bates A, Pegoiani E, Roifman CM, Notarangelo LD (2008). "Variability of clinical and laboratory features among patients with ribonuclease mitochondrial RNA processing endoribonuclease gene mutations.". J Allergy Clin Immunol 122 (6): 1178–84. <a title="Digital object identifier" href="/wiki/Digital_object_identifier">doi</a>:<a class="external text" href="http://dx.doi.org/10.1016%2Fj.jaci.2008.07.036" rel="nofollow">10.1016/j.jaci.2008.07.036</a>. <a class="mw-redirect" title="PubMed Identifier" href="/wiki/PubMed_Identifier">PMID</a> <a class="external text" href="http://www.ncbi.nlm.nih.gov/pubmed/18804272" rel="nofollow">18804272</a>.<span class="Z3988" title="ctx_ver=Z39.88-2004&rft_val_fmt=info%3Aofi%2Ffmt%3Akev%3Amtx%3Ajournal&rft.genre=article&rft.atitle=Variability+of+clinical+and+laboratory+features+among+patients+with+ribonuclease+mitochondrial+RNA+processing+endoribonuclease+gene+mutations.&rft.jtitle=J+Allergy+Clin+Immunol&rft.aulast=Kavadas+FD%2C+Giliani+S%2C+Gu+Y%2C+Mazzolari+E%2C+Bates+A%2C+Pegoiani+E%2C+Roifman+CM%2C+Notarangelo+LD&rft.au=Kavadas+FD%2C+Giliani+S%2C+Gu+Y%2C+Mazzolari+E%2C+Bates+A%2C+Pegoiani+E%2C+Roifman+CM%2C+Notarangelo+LD&rft.date=2008&rft.volume=122&rft.issue=6&rft.pages=1178%E2%80%9384&rft_id=info:doi/10.1016%2Fj.jaci.2008.07.036&rft_id=info:pmid/18804272&rfr_id=info:sid/en.wikipedia.org:Non-coding_RNA"> </li>
<li id="cite_note-pmid18587408-60"><a href="#cite_ref-pmid18587408_60-0">^</a> Faghihi MA, Modarresi F, Khalil AM, Wood DE, Sahagan BG, Morgan TE, Finch CE, St Laurent G, Kenny PJ, Wahlestedt C (2008). <a class="external text" href="http://www.pubmedcentral.nih.gov/articlerender.fcgi?tool=pmcentrez&artid=2826895" rel="nofollow">"Expression of a noncoding RNA is elevated in Alzheimer's disease and drives rapid feed-forward regulation of beta-secretase."</a>. Nat Med 14 (7): 723–30. <a title="Digital object identifier" href="/wiki/Digital_object_identifier">doi</a>:<a class="external text" href="http://dx.doi.org/10.1038%2Fnm1784" rel="nofollow">10.1038/nm1784</a>. <a title="PubMed Central" href="/wiki/PubMed_Central">PMC</a> <a class="external text" href="http://www.pubmedcentral.gov/articlerender.fcgi?tool=pmcentrez&artid=2826895" rel="nofollow">2826895</a>. <a class="mw-redirect" title="PubMed Identifier" href="/wiki/PubMed_Identifier">PMID</a> <a class="external text" href="http://www.ncbi.nlm.nih.gov/pubmed/18587408" rel="nofollow">18587408</a>. <a class="external free" href="http://www.pubmedcentral.nih.gov/articlerender.fcgi?tool=pmcentrez&artid=2826895" rel="nofollow">http://www.pubmedcentral.nih.gov/articlerender.fcgi?tool=pmcentrez&artid=2826895</a>.<span class="Z3988" title="ctx_ver=Z39.88-2004&rft_val_fmt=info%3Aofi%2Ffmt%3Akev%3Amtx%3Ajournal&rft.genre=article&rft.atitle=Expression+of+a+noncoding+RNA+is+elevated+in+Alzheimer%27s+disease+and+drives+rapid+feed-forward+regulation+of+beta-secretase.&rft.jtitle=Nat+Med&rft.aulast=Faghihi+MA%2C+Modarresi+F%2C+Khalil+AM%2C+Wood+DE%2C+Sahagan+BG%2C+Morgan+TE%2C+Finch+CE%2C+St+Laurent+G%2C+Kenny+PJ%2C+Wahlestedt+C&rft.au=Faghihi+MA%2C+Modarresi+F%2C+Khalil+AM%2C+Wood+DE%2C+Sahagan+BG%2C+Morgan+TE%2C+Finch+CE%2C+St+Laurent+G%2C+Kenny+PJ%2C+Wahlestedt+C&rft.date=2008&rft.volume=14&rft.issue=7&rft.pages=723%E2%80%9330&rft_id=info:doi/10.1038%2Fnm1784&rft_id=info:pmc/2826895&rft_id=info:pmid/18587408&rft_id=http%3A%2F%2Fwww.pubmedcentral.nih.gov%2Farticlerender.fcgi%3Ftool%3Dpmcentrez%26artid%3D2826895&rfr_id=info:sid/en.wikipedia.org:Non-coding_RNA"> </li>
<li id="cite_note-pmid19363479-61"><a href="#cite_ref-pmid19363479_61-0">^</a> Mencía A, Modamio-Høybjør S, Redshaw N, Morín M, Mayo-Merino F, Olavarrieta L, Aguirre LA, del Castillo I, Steel KP, Dalmay T, Moreno F, Moreno-Pelayo MA (2009). "Mutations in the seed region of human miR-96 are responsible for nonsyndromic progressive hearing loss.". Nat Genet 41 (5): 609–13. <a title="Digital object identifier" href="/wiki/Digital_object_identifier">doi</a>:<a class="external text" href="http://dx.doi.org/10.1038%2Fng.355" rel="nofollow">10.1038/ng.355</a>. <a class="mw-redirect" title="PubMed Identifier" href="/wiki/PubMed_Identifier">PMID</a> <a class="external text" href="http://www.ncbi.nlm.nih.gov/pubmed/19363479" rel="nofollow">19363479</a>.<span class="Z3988" title="ctx_ver=Z39.88-2004&rft_val_fmt=info%3Aofi%2Ffmt%3Akev%3Amtx%3Ajournal&rft.genre=article&rft.atitle=Mutations+in+the+seed+region+of+human+miR-96+are+responsible+for+nonsyndromic+progressive+hearing+loss.&rft.jtitle=Nat+Genet&rft.aulast=Menc%C3%ADa+A%2C+Modamio-H%C3%B8ybj%C3%B8r+S%2C+Redshaw+N%2C+Mor%C3%ADn+M%2C+Mayo-Merino+F%2C+Olavarrieta+L%2C+Aguirre+LA%2C+del+Castillo+I%2C+Steel+KP%2C+Dalmay+T%2C+Moreno+F%2C+Moreno-Pelayo+MA&rft.au=Menc%C3%ADa+A%2C+Modamio-H%C3%B8ybj%C3%B8r+S%2C+Redshaw+N%2C+Mor%C3%ADn+M%2C+Mayo-Merino+F%2C+Olavarrieta+L%2C+Aguirre+LA%2C+del+Castillo+I%2C+Steel+KP%2C+Dalmay+T%2C+Moreno+F%2C+Moreno-Pelayo+MA&rft.date=2009&rft.volume=41&rft.issue=5&rft.pages=609%E2%80%9313&rft_id=info:doi/10.1038%2Fng.355&rft_id=info:pmid/19363479&rfr_id=info:sid/en.wikipedia.org:Non-coding_RNA"> </li>
<li id="cite_note-pmid19363478-62"><a href="#cite_ref-pmid19363478_62-0">^</a> Lewis MA, Quint E, Glazier AM, Fuchs H, De Angelis MH, Langford C, van Dongen S, Abreu-Goodger C, Piipari M, Redshaw N, Dalmay T, Moreno-Pelayo MA, Enright AJ, Steel KP (2009). <a class="external text" href="http://www.pubmedcentral.nih.gov/articlerender.fcgi?tool=pmcentrez&artid=2705913" rel="nofollow">"An ENU-induced mutation of miR-96 associated with progressive hearing loss in mice."</a>. Nat Genet 41 (5): 614–8. <a title="Digital object identifier" href="/wiki/Digital_object_identifier">doi</a>:<a class="external text" href="http://dx.doi.org/10.1038%2Fng.369" rel="nofollow">10.1038/ng.369</a>. <a title="PubMed Central" href="/wiki/PubMed_Central">PMC</a> <a class="external text" href="http://www.pubmedcentral.gov/articlerender.fcgi?tool=pmcentrez&artid=2705913" rel="nofollow">2705913</a>. <a class="mw-redirect" title="PubMed Identifier" href="/wiki/PubMed_Identifier">PMID</a> <a class="external text" href="http://www.ncbi.nlm.nih.gov/pubmed/19363478" rel="nofollow">19363478</a>. <a class="external free" href="http://www.pubmedcentral.nih.gov/articlerender.fcgi?tool=pmcentrez&artid=2705913" rel="nofollow">http://www.pubmedcentral.nih.gov/articlerender.fcgi?tool=pmcentrez&artid=2705913</a>.<span class="Z3988" title="ctx_ver=Z39.88-2004&rft_val_fmt=info%3Aofi%2Ffmt%3Akev%3Amtx%3Ajournal&rft.genre=article&rft.atitle=An+ENU-induced+mutation+of+miR-96+associated+with+progressive+hearing+loss+in+mice.&rft.jtitle=Nat+Genet&rft.aulast=Lewis+MA%2C+Quint+E%2C+Glazier+AM%2C+Fuchs+H%2C+De+Angelis+MH%2C+Langford+C%2C+van+Dongen+S%2C+Abreu-Goodger+C%2C+Piipari+M%2C+Redshaw+N%2C+Dalmay+T%2C+Moreno-Pelayo+MA%2C+Enright+AJ%2C+Steel+KP&rft.au=Lewis+MA%2C+Quint+E%2C+Glazier+AM%2C+Fuchs+H%2C+De+Angelis+MH%2C+Langford+C%2C+van+Dongen+S%2C+Abreu-Goodger+C%2C+Piipari+M%2C+Redshaw+N%2C+Dalmay+T%2C+Moreno-Pelayo+MA%2C+Enright+AJ%2C+Steel+KP&rft.date=2009&rft.volume=41&rft.issue=5&rft.pages=614%E2%80%938&rft_id=info:doi/10.1038%2Fng.369&rft_id=info:pmc/2705913&rft_id=info:pmid/19363478&rft_id=http%3A%2F%2Fwww.pubmedcentral.nih.gov%2Farticlerender.fcgi%3Ftool%3Dpmcentrez%26artid%3D2705913&rfr_id=info:sid/en.wikipedia.org:Non-coding_RNA"> </li>
<li id="cite_note-pmid19245798-63"><a href="#cite_ref-pmid19245798_63-0">^</a> Soukup GA (2009). <a class="external text" href="http://www.pubmedcentral.nih.gov/articlerender.fcgi?tool=pmcentrez&artid=2700218" rel="nofollow">"Little but loud: Small RNAs have a resounding affect on ear development."</a>. Brain Res 1277: 104–14. <a title="Digital object identifier" href="/wiki/Digital_object_identifier">doi</a>:<a class="external text" href="http://dx.doi.org/10.1016%2Fj.brainres.2009.02.027" rel="nofollow">10.1016/j.brainres.2009.02.027</a>. <a title="PubMed Central" href="/wiki/PubMed_Central">PMC</a> <a class="external text" href="http://www.pubmedcentral.gov/articlerender.fcgi?tool=pmcentrez&artid=2700218" rel="nofollow">2700218</a>. <a class="mw-redirect" title="PubMed Identifier" href="/wiki/PubMed_Identifier">PMID</a> <a class="external text" href="http://www.ncbi.nlm.nih.gov/pubmed/19245798" rel="nofollow">19245798</a>. <a class="external free" href="http://www.pubmedcentral.nih.gov/articlerender.fcgi?tool=pmcentrez&artid=2700218" rel="nofollow">http://www.pubmedcentral.nih.gov/articlerender.fcgi?tool=pmcentrez&artid=2700218</a>.<span class="Z3988" title="ctx_ver=Z39.88-2004&rft_val_fmt=info%3Aofi%2Ffmt%3Akev%3Amtx%3Ajournal&rft.genre=article&rft.atitle=Little+but+loud%3A+Small+RNAs+have+a+resounding+affect+on+ear+development.&rft.jtitle=Brain+Res&rft.aulast=Soukup+GA&rft.au=Soukup+GA&rft.date=2009&rft.volume=1277&rft.pages=104%E2%80%9314&rft_id=info:doi/10.1016%2Fj.brainres.2009.02.027&rft_id=info:pmc/2700218&rft_id=info:pmid/19245798&rft_id=http%3A%2F%2Fwww.pubmedcentral.nih.gov%2Farticlerender.fcgi%3Ftool%3Dpmcentrez%26artid%3D2700218&rfr_id=info:sid/en.wikipedia.org:Non-coding_RNA"> </li>
<li id="cite_note-64"><a href="#cite_ref-64">^</a> Richard J. Carter, Inna Dubchak, Stephen R. Holbrook (2001). <a class="external text" href="http://www.pubmedcentral.nih.gov.oca.ucsc.edu/articlerender.fcgi?artid=60242&rendertype=abstract" rel="nofollow">"A computational approach to identify genes for functional RNAs in genomic sequences"</a>. Nucleic Acids Research 29 (19): 3928–3938. <a title="PubMed Central" href="/wiki/PubMed_Central">PMC</a> <a class="external text" href="http://www.pubmedcentral.gov/articlerender.fcgi?tool=pmcentrez&artid=60242" rel="nofollow">60242</a>. <a class="mw-redirect" title="PubMed Identifier" href="/wiki/PubMed_Identifier">PMID</a> <a class="external text" href="http://www.ncbi.nlm.nih.gov/pubmed/11574674" rel="nofollow">11574674</a>. <a class="external free" href="http://www.pubmedcentral.nih.gov.oca.ucsc.edu/articlerender.fcgi?artid=60242&rendertype=abstract" rel="nofollow">http://www.pubmedcentral.nih.gov.oca.ucsc.edu/articlerender.fcgi?artid=60242&rendertype=abstract</a>.<span class="Z3988" title="ctx_ver=Z39.88-2004&rft_val_fmt=info%3Aofi%2Ffmt%3Akev%3Amtx%3Ajournal&rft.genre=article&rft.atitle=A+computational+approach+to+identify+genes+for+functional+RNAs+in+genomic+sequences&rft.jtitle=Nucleic+Acids+Research&rft.aulast=Richard+J.+Carter%2C+Inna+Dubchak%2C+Stephen+R.+Holbrook&rft.au=Richard+J.+Carter%2C+Inna+Dubchak%2C+Stephen+R.+Holbrook&rft.date=2001&rft.volume=29&rft.issue=19&rft.pages=3928%E2%80%933938&rft_id=info:pmc/60242&rft_id=info:pmid/11574674&rft_id=http%3A%2F%2Fwww.pubmedcentral.nih.gov.oca.ucsc.edu%2Farticlerender.fcgi%3Fartid%3D60242%26rendertype%3Dabstract&rfr_id=info:sid/en.wikipedia.org:Non-coding_RNA"> </li>
<li id="cite_note-65"><a href="#cite_ref-65">^</a> Jakob Skou Pedersen, Gill Bejerano, Adam Siepel, Kate Rosenbloom, Kerstin Lindblad-Toh, Eric S. Lander, Jim Kent, Webb Miller, David Haussler (2006). <a class="external text" href="http://compbiol.plosjournals.org/perlserv/?request=get-document&doi=10.1371/journal.pcbi.0020033" rel="nofollow">"Identification and Classification of Conserved RNA Secondary Structures in the Human Genome"</a>. PLOS Computational Biology 2 (4): e33. <a title="Digital object identifier" href="/wiki/Digital_object_identifier">doi</a>:<a class="external text" href="http://dx.doi.org/10.1371%2Fjournal.pcbi.0020033" rel="nofollow">10.1371/journal.pcbi.0020033</a>. <a title="PubMed Central" href="/wiki/PubMed_Central">PMC</a> <a class="external text" href="http://www.pubmedcentral.gov/articlerender.fcgi?tool=pmcentrez&artid=1440920" rel="nofollow">1440920</a>. <a class="mw-redirect" title="PubMed Identifier" href="/wiki/PubMed_Identifier">PMID</a> <a class="external text" href="http://www.ncbi.nlm.nih.gov/pubmed/16628248" rel="nofollow">16628248</a>. <a class="external free" href="http://compbiol.plosjournals.org/perlserv/?request=get-document&doi=10.1371/journal.pcbi.0020033" rel="nofollow">http://compbiol.plosjournals.org/perlserv/?request=get-document&doi=10.1371/journal.pcbi.0020033</a>.<span class="Z3988" title="ctx_ver=Z39.88-2004&rft_val_fmt=info%3Aofi%2Ffmt%3Akev%3Amtx%3Ajournal&rft.genre=article&rft.atitle=Identification+and+Classification+of+Conserved+RNA+Secondary+Structures+in+the+Human+Genome&rft.jtitle=PLOS+Computational+Biology&rft.aulast=Jakob+Skou+Pedersen%2C+Gill+Bejerano%2C+Adam+Siepel%2C+Kate+Rosenbloom%2C+Kerstin+Lindblad-Toh%2C+Eric+S.+Lander%2C+Jim+Kent%2C+Webb+Miller%2C+David+Haussler&rft.au=Jakob+Skou+Pedersen%2C+Gill+Bejerano%2C+Adam+Siepel%2C+Kate+Rosenbloom%2C+Kerstin+Lindblad-Toh%2C+Eric+S.+Lander%2C+Jim+Kent%2C+Webb+Miller%2C+David+Haussler&rft.date=2006&rft.volume=2&rft.issue=4&rft.pages=e33&rft_id=info:doi/10.1371%2Fjournal.pcbi.0020033&rft_id=info:pmc/1440920&rft_id=info:pmid/16628248&rft_id=http%3A%2F%2Fcompbiol.plosjournals.org%2Fperlserv%2F%3Frequest%3Dget-document%26doi%3D10.1371%2Fjournal.pcbi.0020033&rfr_id=info:sid/en.wikipedia.org:Non-coding_RNA"> </li>
<li id="cite_note-66"><a href="#cite_ref-66">^</a> Tomas Babak, Benjamin J Blencowe, Timothy R Hughes (2007). <a class="external text" href="http://www.pubmedcentral.nih.gov.oca.ucsc.edu/articlerender.fcgi?artid=1803800&rendertype=abstract" rel="nofollow">"Considerations in the identification of functional RNA structural elements in genomic alignments"</a>. BMC Bioinformatics 8 (8): 33. <a title="Digital object identifier" href="/wiki/Digital_object_identifier">doi</a>:<a class="external text" href="http://dx.doi.org/10.1186%2F1471-2105-8-21" rel="nofollow">10.1186/1471-2105-8-21</a>. <a title="PubMed Central" href="/wiki/PubMed_Central">PMC</a> <a class="external text" href="http://www.pubmedcentral.gov/articlerender.fcgi?tool=pmcentrez&artid=1783863" rel="nofollow">1783863</a>. <a class="mw-redirect" title="PubMed Identifier" href="/wiki/PubMed_Identifier">PMID</a> <a class="external text" href="http://www.ncbi.nlm.nih.gov/pubmed/17244370" rel="nofollow">17244370</a>. <a class="external free" href="http://www.pubmedcentral.nih.gov.oca.ucsc.edu/articlerender.fcgi?artid=1803800&rendertype=abstract" rel="nofollow">http://www.pubmedcentral.nih.gov.oca.ucsc.edu/articlerender.fcgi?artid=1803800&rendertype=abstract</a>.<span class="Z3988" title="ctx_ver=Z39.88-2004&rft_val_fmt=info%3Aofi%2Ffmt%3Akev%3Amtx%3Ajournal&rft.genre=article&rft.atitle=Considerations+in+the+identification+of+functional+RNA+structural+elements+in+genomic+alignments&rft.jtitle=BMC+Bioinformatics&rft.aulast=Tomas+Babak%2C+Benjamin+J+Blencowe%2C+Timothy+R+Hughes&rft.au=Tomas+Babak%2C+Benjamin+J+Blencowe%2C+Timothy+R+Hughes&rft.date=2007&rft.volume=8&rft.issue=8&rft.pages=33&rft_id=info:doi/10.1186%2F1471-2105-8-21&rft_id=info:pmc/1783863&rft_id=info:pmid/17244370&rft_id=http%3A%2F%2Fwww.pubmedcentral.nih.gov.oca.ucsc.edu%2Farticlerender.fcgi%3Fartid%3D1803800%26rendertype%3Dabstract&rfr_id=info:sid/en.wikipedia.org:Non-coding_RNA"> </li>
</ol>
</div>
<h2>External links</h2>
<ul>
<li><a class="external text" href="http://jsm-research.imb.uq.edu.au/rnadb" rel="nofollow">Comprehensive database of mammalian ncRNAs</a></li>
<li><a class="external text" href="http://rfam.sanger.ac.uk" rel="nofollow">The Rfam Database</a> — a curated list of hundreds of families of related ncRNAs.</li>
<li><a class="external text" href="http://www.noncode.org/" rel="nofollow">NONCODE.org</a> — a free database of all kinds of noncoding RNAs (except tRNAs and rRNAs).</li>
<li><a class="external text" href="http://www.ncrnadb.trna.ibch.poznan.pl/" rel="nofollow">Joint ncRNA Database</a> — over 30,000 individual sequences from 99 species of bacteria, archaea and eukaryota</li>
</ul>

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