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Created page with "<p><a href="http://www.bionews.org.uk/page_89234.asp">http://www.bionews.org.uk/page_89234.asp</a></p> <h1 class="page-header">Letter abstract</h1> <hr class="separator" /> <p id..."
<p><a href="http://www.bionews.org.uk/page_89234.asp">http://www.bionews.org.uk/page_89234.asp</a></p>
<h1 class="page-header">Letter abstract</h1>
<hr class="separator" />
<p id="cite"><span class="journalname">Nature Genetics</span> <span class="b">39</span>, 645 - 649 (2007) <br />
Published online: 1 April 2007 | <span class="doi"><abbr title="Digital Object Identifier">doi</abbr>:10.1038/ng2022</span></p>
<p id="errorcor"> </p>
<h2 id="atl">Genome-wide association study of prostate cancer identifies a second risk locus at 8q24</h2>
<p id="aug">Meredith Yeager<sup><a title="affiliated with " href="http://www.nature.com/ng/journal/v39/n5/abs/ng2022.html#a1">1</a>,</sup><sup><a title="affiliated with " href="http://www.nature.com/ng/journal/v39/n5/abs/ng2022.html#a2">2</a></sup>, Nick Orr<sup><a title="affiliated with " href="http://www.nature.com/ng/journal/v39/n5/abs/ng2022.html#a3">3</a></sup>, Richard B Hayes<sup><a title="affiliated with " href="http://www.nature.com/ng/journal/v39/n5/abs/ng2022.html#a2">2</a></sup>, Kevin B Jacobs<sup><a title="affiliated with " href="http://www.nature.com/ng/journal/v39/n5/abs/ng2022.html#a4">4</a></sup>, Peter Kraft<sup><a title="affiliated with " href="http://www.nature.com/ng/journal/v39/n5/abs/ng2022.html#a5">5</a></sup>, Sholom Wacholder<sup><a title="affiliated with " href="http://www.nature.com/ng/journal/v39/n5/abs/ng2022.html#a2">2</a></sup>, Mark J Minichiello<sup><a title="affiliated with " href="http://www.nature.com/ng/journal/v39/n5/abs/ng2022.html#a6">6</a></sup>, Paul Fearnhead<sup><a title="affiliated with " href="http://www.nature.com/ng/journal/v39/n5/abs/ng2022.html#a7">7</a></sup>, Kai Yu<sup><a title="affiliated with " href="http://www.nature.com/ng/journal/v39/n5/abs/ng2022.html#a2">2</a></sup>, Nilanjan Chatterjee<sup><a title="affiliated with " href="http://www.nature.com/ng/journal/v39/n5/abs/ng2022.html#a2">2</a></sup>, Zhaoming Wang<sup><a title="affiliated with " href="http://www.nature.com/ng/journal/v39/n5/abs/ng2022.html#a1">1</a>,</sup><sup><a title="affiliated with " href="http://www.nature.com/ng/journal/v39/n5/abs/ng2022.html#a2">2</a></sup>, Robert Welch<sup><a title="affiliated with " href="http://www.nature.com/ng/journal/v39/n5/abs/ng2022.html#a1">1</a>,</sup><sup><a title="affiliated with " href="http://www.nature.com/ng/journal/v39/n5/abs/ng2022.html#a2">2</a></sup>, Brian J Staats<sup><a title="affiliated with " href="http://www.nature.com/ng/journal/v39/n5/abs/ng2022.html#a1">1</a>,</sup><sup><a title="affiliated with " href="http://www.nature.com/ng/journal/v39/n5/abs/ng2022.html#a2">2</a></sup>, Eugenia E Calle<sup><a title="affiliated with " href="http://www.nature.com/ng/journal/v39/n5/abs/ng2022.html#a8">8</a></sup>, Heather Spencer Feigelson<sup><a title="affiliated with " href="http://www.nature.com/ng/journal/v39/n5/abs/ng2022.html#a8">8</a></sup>, Michael J Thun<sup><a title="affiliated with " href="http://www.nature.com/ng/journal/v39/n5/abs/ng2022.html#a8">8</a></sup>, Carmen Rodriguez<sup><a title="affiliated with " href="http://www.nature.com/ng/journal/v39/n5/abs/ng2022.html#a8">8</a></sup>, Demetrius Albanes<sup><a title="affiliated with " href="http://www.nature.com/ng/journal/v39/n5/abs/ng2022.html#a2">2</a></sup>, Jarmo Virtamo<sup><a title="affiliated with " href="http://www.nature.com/ng/journal/v39/n5/abs/ng2022.html#a9">9</a></sup>, Stephanie Weinstein<sup><a title="affiliated with " href="http://www.nature.com/ng/journal/v39/n5/abs/ng2022.html#a2">2</a></sup>, Fredrick R Schumacher<sup><a title="affiliated with " href="http://www.nature.com/ng/journal/v39/n5/abs/ng2022.html#a5">5</a></sup>, Edward Giovannucci<sup><a title="affiliated with " href="http://www.nature.com/ng/journal/v39/n5/abs/ng2022.html#a10">10</a></sup>, Walter C Willett<sup><a title="affiliated with " href="http://www.nature.com/ng/journal/v39/n5/abs/ng2022.html#a10">10</a></sup>, Geraldine Cancel-Tassin<sup><a title="affiliated with " href="http://www.nature.com/ng/journal/v39/n5/abs/ng2022.html#a11">11</a></sup>, Olivier Cussenot<sup><a title="affiliated with " href="http://www.nature.com/ng/journal/v39/n5/abs/ng2022.html#a11">11</a></sup>, Antoine Valeri<sup><a title="affiliated with " href="http://www.nature.com/ng/journal/v39/n5/abs/ng2022.html#a11">11</a></sup>, Gerald L Andriole<sup><a title="affiliated with " href="http://www.nature.com/ng/journal/v39/n5/abs/ng2022.html#a12">12</a></sup>, Edward P Gelmann<sup><a title="affiliated with " href="http://www.nature.com/ng/journal/v39/n5/abs/ng2022.html#a13">13</a></sup>, Margaret Tucker<sup><a title="affiliated with " href="http://www.nature.com/ng/journal/v39/n5/abs/ng2022.html#a2">2</a></sup>, Daniela S Gerhard<sup><a title="affiliated with " href="http://www.nature.com/ng/journal/v39/n5/abs/ng2022.html#a14">14</a></sup>, Joseph F Fraumeni, Jr<sup><a title="affiliated with " href="http://www.nature.com/ng/journal/v39/n5/abs/ng2022.html#a2">2</a></sup>, Robert Hoover<sup><a title="affiliated with " href="http://www.nature.com/ng/journal/v39/n5/abs/ng2022.html#a2">2</a></sup>, David J Hunter<sup><a title="affiliated with " href="http://www.nature.com/ng/journal/v39/n5/abs/ng2022.html#a2">2</a>,</sup><sup><a title="affiliated with " href="http://www.nature.com/ng/journal/v39/n5/abs/ng2022.html#a5">5</a></sup>, Stephen J Chanock<sup><a title="affiliated with " href="http://www.nature.com/ng/journal/v39/n5/abs/ng2022.html#a2">2</a>,</sup><sup><a title="affiliated with " href="http://www.nature.com/ng/journal/v39/n5/abs/ng2022.html#a3">3</a></sup> & Gilles Thomas<sup><a title="affiliated with " href="http://www.nature.com/ng/journal/v39/n5/abs/ng2022.html#a2">2</a></sup></p>
<div id="abs"><a class="backtotop" href="http://www.nature.com/ng/journal/v39/n5/abs/ng2022.html#top">Top<span class="hidden"> of page</span></a>
<p class="lead">Recently, common variants on human chromosome 8q24 were found to be associated with prostate cancer risk. While conducting a genome-wide association study in the Cancer Genetic Markers of Susceptibility project with 550,000 SNPs in a nested case-control study (1,172 cases and 1,157 controls of European origin), we identified a new association at 8q24 with an independent effect on prostate cancer susceptibility. The most significant signal is 70 kb centromeric to the previously reported SNP, rs1447295, but shows little evidence of linkage disequilibrium with it. A combined analysis with four additional studies (total: 4,296 cases and 4,299 controls) confirms association with prostate cancer for rs6983267 in the centromeric locus (<i>P</i> = 9.42 <img style="border-bottom: 0px; border-left: 0px; vertical-align: middle; border-top: 0px; border-right: 0px" alt="times" src="http://www.nature.com/__chars/math/special/times/black/med/base/glyph.gif" /> 10<sup>-13</sup>; heterozygote odds ratio (OR): 1.26, 95% confidence interval (c.i.): 1.13–1.41; homozygote OR: 1.58, 95% c.i.: 1.40–1.78). Each SNP remained significant in a joint analysis after adjusting for the other (rs1447295 <i>P</i> = 1.41 <img style="border-bottom: 0px; border-left: 0px; vertical-align: middle; border-top: 0px; border-right: 0px" alt="times" src="http://www.nature.com/__chars/math/special/times/black/med/base/glyph.gif" /> 10<sup>-11</sup>; rs6983267 <i>P</i> = 6.62 <img style="border-bottom: 0px; border-left: 0px; vertical-align: middle; border-top: 0px; border-right: 0px" alt="times" src="http://www.nature.com/__chars/math/special/times/black/med/base/glyph.gif" /> 10<sup>-10</sup>). These observations, combined with compelling evidence for a recombination hotspot between the two markers, indicate the presence of at least two independent loci within 8q24 that contribute to prostate cancer in men of European ancestry. We estimate that the population attributable risk of the new locus, marked by rs6983267, is higher than the locus marked by rs1447295 (21% versus 9%).</p>
</div>
<p> </p>
<h1 class="page-header">Letter abstract</h1>
<hr class="separator" />
<p id="cite"><span class="journalname">Nature Genetics</span> <span class="b">39</span>, 645 - 649 (2007) <br />
Published online: 1 April 2007 | <span class="doi"><abbr title="Digital Object Identifier">doi</abbr>:10.1038/ng2022</span></p>
<p id="errorcor"> </p>
<h2 id="atl">Genome-wide association study of prostate cancer identifies a second risk locus at 8q24</h2>
<p id="aug">Meredith Yeager<sup><a title="affiliated with " href="http://www.nature.com/ng/journal/v39/n5/abs/ng2022.html#a1">1</a>,</sup><sup><a title="affiliated with " href="http://www.nature.com/ng/journal/v39/n5/abs/ng2022.html#a2">2</a></sup>, Nick Orr<sup><a title="affiliated with " href="http://www.nature.com/ng/journal/v39/n5/abs/ng2022.html#a3">3</a></sup>, Richard B Hayes<sup><a title="affiliated with " href="http://www.nature.com/ng/journal/v39/n5/abs/ng2022.html#a2">2</a></sup>, Kevin B Jacobs<sup><a title="affiliated with " href="http://www.nature.com/ng/journal/v39/n5/abs/ng2022.html#a4">4</a></sup>, Peter Kraft<sup><a title="affiliated with " href="http://www.nature.com/ng/journal/v39/n5/abs/ng2022.html#a5">5</a></sup>, Sholom Wacholder<sup><a title="affiliated with " href="http://www.nature.com/ng/journal/v39/n5/abs/ng2022.html#a2">2</a></sup>, Mark J Minichiello<sup><a title="affiliated with " href="http://www.nature.com/ng/journal/v39/n5/abs/ng2022.html#a6">6</a></sup>, Paul Fearnhead<sup><a title="affiliated with " href="http://www.nature.com/ng/journal/v39/n5/abs/ng2022.html#a7">7</a></sup>, Kai Yu<sup><a title="affiliated with " href="http://www.nature.com/ng/journal/v39/n5/abs/ng2022.html#a2">2</a></sup>, Nilanjan Chatterjee<sup><a title="affiliated with " href="http://www.nature.com/ng/journal/v39/n5/abs/ng2022.html#a2">2</a></sup>, Zhaoming Wang<sup><a title="affiliated with " href="http://www.nature.com/ng/journal/v39/n5/abs/ng2022.html#a1">1</a>,</sup><sup><a title="affiliated with " href="http://www.nature.com/ng/journal/v39/n5/abs/ng2022.html#a2">2</a></sup>, Robert Welch<sup><a title="affiliated with " href="http://www.nature.com/ng/journal/v39/n5/abs/ng2022.html#a1">1</a>,</sup><sup><a title="affiliated with " href="http://www.nature.com/ng/journal/v39/n5/abs/ng2022.html#a2">2</a></sup>, Brian J Staats<sup><a title="affiliated with " href="http://www.nature.com/ng/journal/v39/n5/abs/ng2022.html#a1">1</a>,</sup><sup><a title="affiliated with " href="http://www.nature.com/ng/journal/v39/n5/abs/ng2022.html#a2">2</a></sup>, Eugenia E Calle<sup><a title="affiliated with " href="http://www.nature.com/ng/journal/v39/n5/abs/ng2022.html#a8">8</a></sup>, Heather Spencer Feigelson<sup><a title="affiliated with " href="http://www.nature.com/ng/journal/v39/n5/abs/ng2022.html#a8">8</a></sup>, Michael J Thun<sup><a title="affiliated with " href="http://www.nature.com/ng/journal/v39/n5/abs/ng2022.html#a8">8</a></sup>, Carmen Rodriguez<sup><a title="affiliated with " href="http://www.nature.com/ng/journal/v39/n5/abs/ng2022.html#a8">8</a></sup>, Demetrius Albanes<sup><a title="affiliated with " href="http://www.nature.com/ng/journal/v39/n5/abs/ng2022.html#a2">2</a></sup>, Jarmo Virtamo<sup><a title="affiliated with " href="http://www.nature.com/ng/journal/v39/n5/abs/ng2022.html#a9">9</a></sup>, Stephanie Weinstein<sup><a title="affiliated with " href="http://www.nature.com/ng/journal/v39/n5/abs/ng2022.html#a2">2</a></sup>, Fredrick R Schumacher<sup><a title="affiliated with " href="http://www.nature.com/ng/journal/v39/n5/abs/ng2022.html#a5">5</a></sup>, Edward Giovannucci<sup><a title="affiliated with " href="http://www.nature.com/ng/journal/v39/n5/abs/ng2022.html#a10">10</a></sup>, Walter C Willett<sup><a title="affiliated with " href="http://www.nature.com/ng/journal/v39/n5/abs/ng2022.html#a10">10</a></sup>, Geraldine Cancel-Tassin<sup><a title="affiliated with " href="http://www.nature.com/ng/journal/v39/n5/abs/ng2022.html#a11">11</a></sup>, Olivier Cussenot<sup><a title="affiliated with " href="http://www.nature.com/ng/journal/v39/n5/abs/ng2022.html#a11">11</a></sup>, Antoine Valeri<sup><a title="affiliated with " href="http://www.nature.com/ng/journal/v39/n5/abs/ng2022.html#a11">11</a></sup>, Gerald L Andriole<sup><a title="affiliated with " href="http://www.nature.com/ng/journal/v39/n5/abs/ng2022.html#a12">12</a></sup>, Edward P Gelmann<sup><a title="affiliated with " href="http://www.nature.com/ng/journal/v39/n5/abs/ng2022.html#a13">13</a></sup>, Margaret Tucker<sup><a title="affiliated with " href="http://www.nature.com/ng/journal/v39/n5/abs/ng2022.html#a2">2</a></sup>, Daniela S Gerhard<sup><a title="affiliated with " href="http://www.nature.com/ng/journal/v39/n5/abs/ng2022.html#a14">14</a></sup>, Joseph F Fraumeni, Jr<sup><a title="affiliated with " href="http://www.nature.com/ng/journal/v39/n5/abs/ng2022.html#a2">2</a></sup>, Robert Hoover<sup><a title="affiliated with " href="http://www.nature.com/ng/journal/v39/n5/abs/ng2022.html#a2">2</a></sup>, David J Hunter<sup><a title="affiliated with " href="http://www.nature.com/ng/journal/v39/n5/abs/ng2022.html#a2">2</a>,</sup><sup><a title="affiliated with " href="http://www.nature.com/ng/journal/v39/n5/abs/ng2022.html#a5">5</a></sup>, Stephen J Chanock<sup><a title="affiliated with " href="http://www.nature.com/ng/journal/v39/n5/abs/ng2022.html#a2">2</a>,</sup><sup><a title="affiliated with " href="http://www.nature.com/ng/journal/v39/n5/abs/ng2022.html#a3">3</a></sup> & Gilles Thomas<sup><a title="affiliated with " href="http://www.nature.com/ng/journal/v39/n5/abs/ng2022.html#a2">2</a></sup></p>
<div id="abs"><a class="backtotop" href="http://www.nature.com/ng/journal/v39/n5/abs/ng2022.html#top">Top<span class="hidden"> of page</span></a>
<p class="lead">Recently, common variants on human chromosome 8q24 were found to be associated with prostate cancer risk. While conducting a genome-wide association study in the Cancer Genetic Markers of Susceptibility project with 550,000 SNPs in a nested case-control study (1,172 cases and 1,157 controls of European origin), we identified a new association at 8q24 with an independent effect on prostate cancer susceptibility. The most significant signal is 70 kb centromeric to the previously reported SNP, rs1447295, but shows little evidence of linkage disequilibrium with it. A combined analysis with four additional studies (total: 4,296 cases and 4,299 controls) confirms association with prostate cancer for rs6983267 in the centromeric locus (<i>P</i> = 9.42 <img style="border-bottom: 0px; border-left: 0px; vertical-align: middle; border-top: 0px; border-right: 0px" alt="times" src="http://www.nature.com/__chars/math/special/times/black/med/base/glyph.gif" /> 10<sup>-13</sup>; heterozygote odds ratio (OR): 1.26, 95% confidence interval (c.i.): 1.13–1.41; homozygote OR: 1.58, 95% c.i.: 1.40–1.78). Each SNP remained significant in a joint analysis after adjusting for the other (rs1447295 <i>P</i> = 1.41 <img style="border-bottom: 0px; border-left: 0px; vertical-align: middle; border-top: 0px; border-right: 0px" alt="times" src="http://www.nature.com/__chars/math/special/times/black/med/base/glyph.gif" /> 10<sup>-11</sup>; rs6983267 <i>P</i> = 6.62 <img style="border-bottom: 0px; border-left: 0px; vertical-align: middle; border-top: 0px; border-right: 0px" alt="times" src="http://www.nature.com/__chars/math/special/times/black/med/base/glyph.gif" /> 10<sup>-10</sup>). These observations, combined with compelling evidence for a recombination hotspot between the two markers, indicate the presence of at least two independent loci within 8q24 that contribute to prostate cancer in men of European ancestry. We estimate that the population attributable risk of the new locus, marked by rs6983267, is higher than the locus marked by rs1447295 (21% versus 9%).</p>
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