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<strong><font size="4">Study</font></strong><br />
In a genomewide association study of 393 RLS patients and 1602 controls, Winkelmann et al. (2007) found a significant association between RLS and dbSNP rs2300478 in the MEIS1 gene (601739). The findings were confirmed in 2 independent replication studies of 875 and 211 patients, respectively. Combined results of all 3 studies yielded an overall odds ratio of 1.74 for the G allele (p = 8.08 x 10(-23)). The study also showed evidence for an association with several SNPs within a region on chromosome 15q that contains the LBXCOR1 (611273) and MAP2K5 (602520) genes.<br />
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<font size="4"><strong>Other information</strong></font><br />
GENE: RLS1<br />
CYTO: 12q12-q21<br />
DESC: Restless legs syndrome, susceptibility to, 1<br />
SNP : rs2300478<br /><br />In a genomewide association study of 393 RLS patients and 1602 controls,<br />Winkelmann et al. (2007) found a significant association between RLS and<br />dbSNP rs2300478 in the MEIS1 gene (601739). The findings were confirmed<br />in 2 independent replication studies of 875 and 211 patients,<br />respectively. Combined results of all 3 studies yielded an overall odds<br />ratio of 1.74 for the G allele (p = 8.08 x 10(-23)). The study also<br />showed evidence for an association with several SNPs within a region on<br />chromosome 15q that contains the LBXCOR1 (611273) and MAP2K5 (602520)<br />genes.<br />
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<font size="4"><strong>Reference</strong></font><br />
Winkelmann, J.; Schormair, B.; Lichtner, P.; Ripke, S.; Xiong, L.; Jalilzadeh, S.; Fulda, S.; Putz, B.; Eckstein, G.; Hauk, S.; Trenkwalder, C.; Zimprich, A.; and 15 others : <br />
:Genome-wide association study of restless legs syndrome identifies common variants in three genomic regions. Nature Genet. 39: 1000-1006, 2007. PubMed ID : 17637780<br />