Changes

<strong><font size="4">Study</font></strong><br />

In a genomewide association study of 393 RLS patients and 1602 controls, Winkelmann et al. (2007) found a significant association between [[restless legs syndrome]] and dbSNP rs2300478 in the MEIS1 gene (601739). The findings were confirmed in 2 independent replication studies of 875 and 211 patients, respectively. Combined results of all 3 studies yielded an overall odds ratio of 1.74 for the G allele (p = 8.08 x 10(-23)). The study also showed evidence for an association with several SNPs within a region on chromosome 15q that contains the LBXCOR1 (611273) and MAP2K5 (602520) genes.<br />

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<font size="4"><strong>Other information</strong></font><br />