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<p><span style="color: #000000"><i><b>Mycoplasma genitalium</b></i> is a small parasitic bacterium which lives on the ciliated epithelial cells of the primate genital and respiratory tracts. <i>M. genitalium</i> is the smallest known free-living bacterium, and the second-smallest bacterium after the recently-discovered endosymbiont <i>Carsonella ruddii</i>. Until the discovery of <i>Nanoarchaeum</i> in 2002, <i>M. genitalium</i> was also considered to be the organism with the smallest genome.<sup id="cite_ref-0" class="reference"><font size="2">[1]</font></sup></span></p>

<h2><span style="color: #000000"><span id="Overview" class="mw-headline">Overview</span></span></h2>

<p><span style="color: #000000"><i>Mycoplasma genitalium</i> was originally isolated in 1980 from urethral specimens of two male patients with non-gonococcal urethritis. Infection by <i>M. genitalium</i> seems fairly common, can be transmitted between partners during unprotected sexual intercourse, and can be treated with antibiotics; however, the organism's role in genital diseases is still unclear.</span></p>