유효정

HyoJung Ryu

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Education

• 2011/03 - 2018/08 : Combined M.S/Ph.D. in Bioinformatics, UST (University of Science and Technology) KRIBB school, Daejeon, Korea
• 2009/05 - 2011/02 : B.S. in Computer Science, NILE (National Institute for Lifelong Education), Seoul, Korea                               

Career

• 2019/04 - Present : Post-doctoral researcher, UNIST KOGIC, Ulsan, Korea
• 2018/10 - 2019/02 : Researcher, KRIBB, Daejeon, Korea

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Research topics

1. Development of prediction score of protein function change by a genetic mutation

• Protein 3D structure modeling 
  • ​I-TASSER, RaptorX, Rosetta
• Evaluation of protein structural features ( Geometrical/Stereo-chemical features)
  • PROCHECK, WHAT_CHECK, MolProbity
• Scoring function development

 

    2. Antigenic peptide-MHC binding affinity prediction with MD

• Molecular Dynamics(MD) simulation
  • ​Gromacs(2019.03 ver), Tinker
• Binding affinity prediction
  • ​FoldX
• IEDB big data
  • ​HLA-A type peptide list
    • Specific alleles : ​HLA-A*02:01, HLA-A*02:24 

  

2-1. Workflow - Generate reference set (MHC class I)